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231223s2007 xx ||||| 00| ||chi c |
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|a (DE-627)NLM174953135
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|a (NLM)17996136
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a chi
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|a Gan, Run-tao
|e verfasserin
|4 aut
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|a Effect of beta3-adrenoceptor antagonist on the cardiac function and expression of endothelial nitric oxide synthase in a rat model of heart failure
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|c 2007
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|a Text
|b txt
|2 rdacontent
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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|a Band
|b nc
|2 rdacarrier
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|a Date Completed 08.10.2009
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|a Date Revised 18.11.2010
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|a published: Print
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|a Citation Status MEDLINE
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|a OBJECTIVE: To investigate the effect of beta(3)-adrenoceptor (beta(3)-AR) antagonist (SR59230A) on the cardiac function and left ventricular remodeling in a rat model of heart failure induced by isoproterenol (ISO), and to probe into its mechanism
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|a METHODS: Eight rats were randomly selected to serve as controls from 85 male adult Wistar rats. After a heart failure model was reproduced, twenty remain rats were randomly divided into ISO group (n = 10) and SR59230A group (SR group, n = 10). ISO group received intraperitoneal injection of 1 ml saline twice a day; SR group received intraperitoneal injection of 85 nmol SR59230A in 1 ml saline twice a day; control group received no treatment. The parameters determined included echocardiogram, the expression of nitric oxide synthase (eNOS) of left ventricle by the technique of reverse transcription-polymerase chain reaction (RT-PCR) and Western blotting, cyclic guanosine monophosphate (cGMP) level by enzyme linked immunosorbent assay (ELISA), the ratio of left ventricular weight and body weight (LVW/BW), and the ratio of lung weight and body weight (PW/BW)
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|a RESULTS: Compared with control group, the left ventricular end systolic pressure (LVESP), the maximum and minimum first derivative of left ventricular pressure (+/-dp/dtmax) were significantly decreased (all P<0.01), while heart rate (HR) and left ventricular end-diastolic pressure (LVEDP) were significantly increased (both P<0.01) in ISO group. Compared with ISO group, LVESP, +/-dp/dtmax were markedly higher (P<0.05 or P<0.01) respectively, whereas HR and LVEDP were markedly lower (P<0.05 and P<0.01) in SR group, and there was no difference in HR between SR group and control group (P>0.05), while LVEDP was higher in RS group than control group (P<0.01). The levels of eNOS mRNA, protein and cGMP were significantly lower in SR group compared with ISO group (all P<0.01). In addition, when compared with ISO group, LVW/BW ratio and PW/BW ratio in SR group were also decreased (both P<0.05)
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|a CONCLUSION: beta(3)-AR antagonist SR59230A can block the beta(3)-AR-NOS-cGMP pathway and improve cardiac function in heart failure in rat when if is administered for a long term. SR59230A can also improve left ventricular remodeling in a certain degree
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|a English Abstract
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a 3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate
|2 NLM
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|a Adrenergic beta-3 Receptor Antagonists
|2 NLM
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|a Propanolamines
|2 NLM
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|a RNA, Messenger
|2 NLM
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|a Nitric Oxide Synthase Type III
|2 NLM
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|a EC 1.14.13.39
|2 NLM
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| 700 |
1 |
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|a Li, Wei-min
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Xu
|e verfasserin
|4 aut
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|a Wu, Shuang
|e verfasserin
|4 aut
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|a Kong, Yi-hui
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue
|d 1998
|g 19(2007), 11 vom: 12. Nov., Seite 675-8
|w (DE-627)NLM098227793
|x 1003-0603
|7 nnns
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| 773 |
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|g volume:19
|g year:2007
|g number:11
|g day:12
|g month:11
|g pages:675-8
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|a GBV_USEFLAG_A
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|a SYSFLAG_A
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|a GBV_NLM
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|a GBV_ILN_350
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|a AR
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|d 19
|j 2007
|e 11
|b 12
|c 11
|h 675-8
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