Significance of the ratio of circulating endothelial cell expressing endothelial lipase and supersensitivity C-reactive protein in prognosis of patients with coronary artery disease

OBJECTIVE: To evaluate the significance of the ratio of circulating endothelial cell expressing endothelial lipase (EL(+)/CECs) and supersensitivity C-reactive protein (hsCRP) in prognosis of patients with coronary artery disease (CAD)

Bibliographische Detailangaben
Veröffentlicht in:Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue. - 1998. - 19(2007), 11 vom: 12. Nov., Seite 644-6
1. Verfasser: Fang, Yu-qiang (VerfasserIn)
Weitere Verfasser: Huang, Lan, Li, Ai-min, Song, Yao-ming, Jin, Jun, Geng, Zhao-hua, Yu, Xue-jun, Deng, Meng-yang
Format: Aufsatz
Sprache:Chinese
Veröffentlicht: 2007
Zugriff auf das übergeordnete Werk:Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue
Schlagworte:Journal Article Research Support, Non-U.S. Gov't C-Reactive Protein 9007-41-4 LIPG protein, human EC 3.1.1.3 Lipase
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245 1 0 |a Significance of the ratio of circulating endothelial cell expressing endothelial lipase and supersensitivity C-reactive protein in prognosis of patients with coronary artery disease 
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500 |a Citation Status MEDLINE 
520 |a OBJECTIVE: To evaluate the significance of the ratio of circulating endothelial cell expressing endothelial lipase (EL(+)/CECs) and supersensitivity C-reactive protein (hsCRP) in prognosis of patients with coronary artery disease (CAD) 
520 |a METHODS: one hundred and seven patients with acute coronary syndrome (ACS), 69 patients with stable angina pain (SAP), and 82 patients in whom CAD was excluded to serve as control were included for study. Blood samples were collected from ulnar vein, and hsCRP was detected, circulating endothelial cells (CECs) were isolated, and the ratio of CEC (EL(+)/CECs) which expressed endothelial lipase (EL) was determined by immunohistochemistry. Over a follow-up period of 6 months, the incidence of cardiac event of all patients was recorded 
520 |a RESULTS: In patients with CAD, the EL(+)/CECs and hsCRP were significantly different among groups (P<0.05 or P<0.01). Among them, hsCRP and EL(+)/CECs were higher in ACS group than SAP group patients, whose hsCRP and EL(+)/CECs higher than the control group. The incidence rate of cardiovascular event was significantly higher (all P<0.01) in those whose hsCRP or EL(+)/CECs was higher than those whose with lower average values of these two parameters. Regression analysis indicated that the EL(+)/CECs and hsCRP could be used as the prognostic factor of CAD. The prognostic value of combined determination of EL(+)/CECs and hsCRP was higher 
520 |a CONCLUSION: The expression of EL in endothelial cells may play a role in the progression of CAD. The EL(+)/CECs may be a good prognostic factor. EL(+)/CECs together with hsCRP may increase the prognostic value 
650 4 |a Journal Article 
650 4 |a Research Support, Non-U.S. Gov't 
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700 1 |a Huang, Lan  |e verfasserin  |4 aut 
700 1 |a Li, Ai-min  |e verfasserin  |4 aut 
700 1 |a Song, Yao-ming  |e verfasserin  |4 aut 
700 1 |a Jin, Jun  |e verfasserin  |4 aut 
700 1 |a Geng, Zhao-hua  |e verfasserin  |4 aut 
700 1 |a Yu, Xue-jun  |e verfasserin  |4 aut 
700 1 |a Deng, Meng-yang  |e verfasserin  |4 aut 
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