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DE-627 |
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20250208200909.0 |
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231223s2008 xx ||||| 00| ||eng c |
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|a pubmed25n0583.xml
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|a (DE-627)NLM174747837
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|a (NLM)17974483
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Lin, Yi
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a TSLP-induced placental DC activation and IL-10(+) NK cell expansion
|b comparative study based on BALB/c x C57BL/6 and NOD/SCID x C57BL/6 pregnant models
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| 264 |
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1 |
|c 2008
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 25.02.2008
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| 500 |
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|a Date Revised 07.12.2022
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| 500 |
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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| 520 |
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|a Thymic stromal lymphopoietin (TSLP)-TSLP receptor (TSLP-R) interactions activate CD11c(+) dendritic cells (DCs) and increase epithelial cell Th2-type cytokine production. We detected intracellular TSLP expression on CK7(+) trophoblast cells and TSLP-R expression on placental DCs from pregnant BALB/cxC57BL/6 and NOD/SCIDxC57BL/6 mice on gestational day 12.5. Murine recombinant TSLP activated DCs from BALB/c mice, with increased CD80 and CD83 expressions; TSLP-activated DCs induced IL-10-producing NK cell expansion. This was abrogated by anti-TSLP Ab or by culturing CD49b(+) NK cells alone. No TSLP-DC-induced IL-10(+)CD49b(+) cell expansion occurred when DCs and CD49b(+) cells were cultured separately. Although TSLP-induced DC activation occurred in NOD/SCID mice, the IL-10(+) NK cell percentage was unchanged. CK7(+) trophoblast cells may activate placental DCs via a TSLP-TSLP-R interaction and induce DC-dependent placental NK cell IL-10 production. TSLP-DC and NK cell contact appears necessary for IL-10(+)CD49b(+) cell expansion. Placental NK cells from NOD/SCIDxC57BL/6 mice appear less sensitive to TSLP-DC induction
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| 650 |
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4 |
|a Comparative Study
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| 650 |
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|a Journal Article
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| 650 |
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|a Research Support, Non-U.S. Gov't
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| 650 |
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|a Cytokines
|2 NLM
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| 650 |
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|a Immunoglobulins
|2 NLM
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| 650 |
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7 |
|a Receptors, Cytokine
|2 NLM
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| 650 |
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|a Tslpr protein, mouse
|2 NLM
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| 650 |
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|a Interleukin-10
|2 NLM
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| 650 |
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7 |
|a 130068-27-8
|2 NLM
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| 650 |
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|a Interferon-gamma
|2 NLM
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| 650 |
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7 |
|a 82115-62-6
|2 NLM
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| 650 |
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7 |
|a Thymic Stromal Lymphopoietin
|2 NLM
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| 650 |
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7 |
|a GT0IL38SP4
|2 NLM
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| 650 |
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7 |
|a TSLP protein, mouse
|2 NLM
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| 700 |
1 |
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|a Zhong, Yanmin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Shen, Weizai
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, Yijing
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Shi, Jianbo
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Di, Jingfang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zeng, Shan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Saito, Shigeru
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 126(2008), 1 vom: 17. Jan., Seite 104-17
|w (DE-627)NLM098196855
|x 1521-6616
|7 nnns
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| 773 |
1 |
8 |
|g volume:126
|g year:2008
|g number:1
|g day:17
|g month:01
|g pages:104-17
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| 912 |
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_11
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| 912 |
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|a GBV_ILN_24
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 126
|j 2008
|e 1
|b 17
|c 01
|h 104-17
|