Interferon-gamma and tumor necrosis factor-alpha disrupt epithelial barrier function by altering lipid composition in membrane microdomains of tight junction
Tight junctions (TJs) are specialized membrane microdomains of plasma membrane and play an important role in barrier function. IFN-gamma and TNF-alpha have been implicated in intestinal barrier dysfunction. In the present study, we analyzed the effect of IFN-gamma and TNF-alpha on epithelial barrier...
| Publié dans: | Clinical immunology (Orlando, Fla.). - 1999. - 126(2008), 1 vom: 08. Jan., Seite 67-80 |
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| Auteur principal: | |
| Autres auteurs: | , , , , , , , , |
| Format: | Article |
| Langue: | English |
| Publié: |
2008
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| Accès à la collection: | Clinical immunology (Orlando, Fla.) |
| Sujets: | Journal Article Research Support, Non-U.S. Gov't Fatty Acids Membrane Lipids Membrane Proteins OCLN protein, human Occludin Phospholipids Tumor Necrosis Factor-alpha flotillins plus... |