Abatacept modulates human dendritic cell-stimulated T-cell proliferation and effector function independent of IDO induction

Abatacept modulates human dendritic cell-stimulated T-cell proliferation and effector function independent of IDO induction

Abatacept, the first in a new class of agents for RA, modulates CD28-mediated T-cell costimulation. Abatacept was evaluated for its ability to regulate human T-cell proliferation and cytokine production initiated by dendritic cells. Abatacept reduced T-cell proliferation by >95% at concentrations...

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Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 126(2008), 1 vom: 15. Jan., Seite 38-47
1. Verfasser: Davis, Patricia M (VerfasserIn)
Weitere Verfasser: Nadler, Steven G, Stetsko, Dawn K, Suchard, Suzanne J
Format: Aufsatz
Sprache:English
Veröffentlicht: 2008
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Cytokines Immunoconjugates Immunosuppressive Agents Indoleamine-Pyrrole 2,3,-Dioxygenase RNA, Messenger Tetanus Toxoid Kynurenine 343-65-7 Abatacept 7D0YB67S97