CD8(+) T cells specific for both persistent and non-persistent viruses display distinct differentiation phenotypes but have similar level of PD-1 expression in healthy Chinese individuals

CD8(+) T cells specific for both persistent and non-persistent viruses display distinct differentiation phenotypes but have similar level of PD-1 expression in healthy Chinese individuals

Anti-viral CD8(+) T cell responses involve an initial expansion and effector phase, followed by contraction phase and formation of CD8(+) memory T cells. During this contraction phase, increased surface expression of the negative regulator PD-1 is associated with functional exhaustion of CD8(+) T ce...

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Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 126(2008), 2 vom: 01. Feb., Seite 222-34
1. Verfasser: He, Xian-Hui (VerfasserIn)
Weitere Verfasser: Jia, Qian-Tao, Li, Feng-Yao, Saltis, Mark, Liu, Yi, Xu, Li-Hui, Zha, Qing-Bing
Format: Aufsatz
Sprache:English
Veröffentlicht: 2008
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Antigens, CD Apoptosis Regulatory Proteins B7-H1 Antigen CD274 protein, human CD28 Antigens Interleukin-7 Receptor alpha Subunit PDCD1 protein, human Programmed Cell Death 1 Receptor Tumor Necrosis Factor Receptor Superfamily, Member 7