Role of ICOS pathway in autoimmune and alloimmune responses in NOD mice

Role of ICOS pathway in autoimmune and alloimmune responses in NOD mice

Islet allografts are subject to alloimmune and autoimmune destruction when transplanted into autoimmune prone animals or humans. The ICOS-B7h pathway plays a role in alloimmune responses, but its function in autoimmunity against islet cells is controversial. We investigated the role of ICOS signalin...

Ausführliche Beschreibung

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 126(2008), 2 vom: 15. Feb., Seite 140-7
1. Verfasser: Ansari, Mohammed Javeed I (VerfasserIn)
Weitere Verfasser: Fiorina, Paolo, Dada, Shirine, Guleria, Indira, Ueno, Takuya, Yuan, Xueli, Trikudanathan, Subbulaxmi, Smith, R Neal, Freeman, Gordon, Sayegh, Mohamed H
Format: Aufsatz
Sprache:English
Veröffentlicht: 2008
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Antibodies, Monoclonal Antigens, Differentiation, T-Lymphocyte ICOS protein, human Icos protein, mouse Immunologic Factors Immunosuppressive Agents Inducible T-Cell Co-Stimulator Protein mehr... Sirolimus W36ZG6FT64