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01000naa a22002652 4500 |
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NLM173370195 |
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DE-627 |
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20231223133649.0 |
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tu |
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231223s2007 xx ||||| 00| ||eng c |
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|a pubmed24n0578.xml
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|a (DE-627)NLM173370195
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|a (NLM)17827068
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Dessing, Mark C
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Monocyte chemoattractant protein 1 contributes to an adequate immune response in influenza pneumonia
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| 264 |
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1 |
|c 2007
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 22.01.2008
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| 500 |
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|a Date Revised 21.11.2008
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| 500 |
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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| 520 |
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|a Monocyte chemoattractant protein 1 (MCP-1) and its receptor CCR2 have been shown to play an import role in leukocyte recruitment to sites of infection and inflammation. To investigate the role of MCP-1 during infection with influenza we inoculated wild-type (WT) and MCP-1 knockout (KO) mice with a non-lethal dose of a mouse adapted strain of influenza A. Influenza infection of WT mice resulted in a profound increase in pulmonary MCP-1 levels. MCP-1 KO mice had enhanced weight loss and did not fully regain their body weight during the 14-day observation period. In addition, MCP-1 KO mice demonstrated elevated viral loads 8 days after infection, which was accompanied by reduced leukocyte recruitment into the infected lungs, primarily caused by a diminished influx of macrophages and granulocytes. Moreover, pulmonary levels of IgA were reduced in MCP-1 KO mice. The pulmonary concentrations of tumor necrosis factor-alpha, interleukin-6, macrophage inflammatory protein 2 and interferon-gamma were higher in MCP-1 KO mice. This study shows that MCP-1 contributes to an adequate protective immune response against influenza infection in mice
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| 650 |
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|a Journal Article
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| 650 |
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7 |
|a Ccl2 protein, mouse
|2 NLM
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| 650 |
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7 |
|a Chemokine CCL2
|2 NLM
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| 650 |
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7 |
|a Chemokine CXCL2
|2 NLM
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| 650 |
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7 |
|a Interleukin-6
|2 NLM
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| 650 |
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7 |
|a Tumor Necrosis Factor-alpha
|2 NLM
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| 650 |
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7 |
|a Interferon-gamma
|2 NLM
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| 650 |
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7 |
|a 82115-62-6
|2 NLM
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| 700 |
1 |
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|a van der Sluijs, Koenraad F
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Florquin, Sandrine
|e verfasserin
|4 aut
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| 700 |
1 |
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|a van der Poll, Tom
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 125(2007), 3 vom: 08. Dez., Seite 328-36
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:125
|g year:2007
|g number:3
|g day:08
|g month:12
|g pages:328-36
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| 912 |
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|a AR
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| 952 |
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|d 125
|j 2007
|e 3
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|c 12
|h 328-36
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