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01000caa a22002652 4500 |
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NLM173164609 |
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DE-627 |
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20250208155726.0 |
| 007 |
tu |
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231223s2007 xx ||||| 00| ||eng c |
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5 |
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|a pubmed25n0577.xml
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|a (DE-627)NLM173164609
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| 035 |
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|a (NLM)17806080
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Suter, Steven E
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a CD34+, CD41+ acute megakaryoblastic leukemia in a dog
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| 264 |
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1 |
|c 2007
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 13.11.2007
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| 500 |
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|a Date Revised 10.11.2019
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| 500 |
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|a published: Print
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| 500 |
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|a Citation Status MEDLINE
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| 520 |
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|a A clinically normal, 5-year-old intact female German Shepherd dog was presented to the local veterinarian to be spayed. Results of a preoperative CBC included mild nonregenerative anemia, severe thrombocytopenia, and 17% unclassified cells. On cytologic examination of aspirates from the dog's enlarged spleen and peripheral lymph nodes, a population of primitive round cells that occasionally resembled megakaryocytes was observed. A bone marrow aspirate specimen was markedly hypercellular with approximately 65% of marrow cells comprising a homogeneous population of immature hematopoietic cells similar to those found in the spleen, lymph nodes, and peripheral blood. Using immunocytochemical stains with canine-specific antibodies, all neoplastic cells strongly expressed cytoplasmic CD41 and 20-70% of the neoplastic cells expressed CD34 weakly to moderately. Rare (<0.5%) neoplastic cells weakly expressed vWF. The cells were negative for all other markers. Based on these results and the morphology of the neoplastic cells, a diagnosis of acute megakaryoblastic leukemia (AMegL) was made. In spite of treatment, results of a CBC performed 1 week later indicated progressive anemia and thrombocytopenia, and the dog was euthanized. To our knowledge, this report documents the first case of canine AMegL diagnosed with both anti-canine CD34 and CD41 antibodies
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| 650 |
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4 |
|a Case Reports
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| 650 |
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4 |
|a Journal Article
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| 650 |
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7 |
|a Antibodies
|2 NLM
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| 650 |
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7 |
|a Antigens, CD34
|2 NLM
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| 650 |
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7 |
|a Platelet Membrane Glycoprotein IIb
|2 NLM
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| 700 |
1 |
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|a Vernau, William
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Fry, Michael M
|e verfasserin
|4 aut
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| 700 |
1 |
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|a London, Cheryl A
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Veterinary clinical pathology
|d 1975
|g 36(2007), 3 vom: 01. Sept., Seite 288-92
|w (DE-627)NLM098159984
|x 0275-6382
|7 nnns
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| 773 |
1 |
8 |
|g volume:36
|g year:2007
|g number:3
|g day:01
|g month:09
|g pages:288-92
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| 912 |
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 36
|j 2007
|e 3
|b 01
|c 09
|h 288-92
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