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231223s2007 xx ||||| 00| ||eng c |
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|a pubmed25n0575.xml
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|a (NLM)17720627
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Wei, Ye-Sheng
|e verfasserin
|4 aut
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| 245 |
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|a Single nucleotide polymorphism and haplotype association of the interleukin-8 gene with nasopharyngeal carcinoma
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| 264 |
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|c 2007
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 22.01.2008
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|a Date Revised 18.03.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a The cytokine interleukin-8 (IL-8) may play a role in the pathogenesis of nasopharyngeal carcinoma (NPC) through the modulation of tumor immune response or enhanced angiogenesis. Polymorphism of IL-8 gene, which may affect the production level of cytokine, has been inversely associated with a number of cancers. To test this hypothesis, we investigated the relationship of IL-8 gene polymorphisms and NPC in a Chinese population. We analyzed single nucleotide polymorphisms (SNPs) of IL-8 gene -845 T/C, -738 T/A, -353 A/T, -251 A/T and +678 T/C in 280 patients with NPC and 290 age and sex matched controls, using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and polymerase chain reaction-sequence specific primers method (PCR-SSP). There were significant differences in the genotype and allele distribution of -251 A/T polymorphism of the IL-8 gene among cases and controls. The -251 AA and AT genotypes were associated with a significantly increased risk of NPC as compared with the -251 TT genotypes (OR=1.820, 95% CI, 1.120-2.959, P=0.015 and OR=1.590, 95% CI, 1.104-2.290, P=0.013, respectively). Haplotype analysis revealed that the homozygosity of the AAT haplotype (defined by SNPs at positions -353, -251 and +678) of IL-8 gene conveys the highest risk for NPC compared with the homozygosity for the TTC haplotype (OR=1.396; 95% CI, 1.064-1.831; P=0.016). The -251 A/T polymorphism of IL-8 and its haplotype are associated with NPC in a Chinese population. Our data suggests that IL-8 gene may play a role in the development of NPC
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|a Journal Article
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| 650 |
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|a Research Support, Non-U.S. Gov't
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| 650 |
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7 |
|a DNA Primers
|2 NLM
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| 650 |
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|a Interleukin-8
|2 NLM
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| 700 |
1 |
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|a Lan, Yan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tang, Ren-Guang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xu, Qun-Qing
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Huang, Yan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Nong, Hong-Bing
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Huang, Wei-Tong
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 125(2007), 3 vom: 01. Dez., Seite 309-17
|w (DE-627)NLM098196855
|x 1521-6616
|7 nnns
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| 773 |
1 |
8 |
|g volume:125
|g year:2007
|g number:3
|g day:01
|g month:12
|g pages:309-17
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|d 125
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|h 309-17
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