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01000caa a22002652 4500 |
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NLM172214912 |
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DE-627 |
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20250208141506.0 |
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tu |
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231223s2007 xx ||||| 00| ||chi c |
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|a pubmed25n0574.xml
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|a (DE-627)NLM172214912
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|a (NLM)17708848
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a chi
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| 100 |
1 |
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|a Li, Yin-ping
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Effects of Xuebijing injection on protein C and tumor necrosis factor-alpha mRNA in rats with sepsis
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| 264 |
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1 |
|c 2007
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 06.10.2009
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| 500 |
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|a Date Revised 21.08.2007
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|a published: Print
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|a Citation Status MEDLINE
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| 520 |
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|a OBJECTIVE: To investigate the effects of the integrated traditional Chinese medicine Xuebijing injection on protein C (PC) and tumor necrosis factor-alpha (TNF-alpha) mRNA in rats with sepsis
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| 520 |
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|a METHODS: Sepsis was induced in Wistar rats by cecal ligation and puncture (CLP). Ninety-six healthy animals were randomly divided into four groups: normal group, sham-operation group, CLP model group, and Xuebijing-treated group. The two latter groups were divided into 2, 8, 24, 48, and 72-hour subgroups with 8 rats in each subgroup. Platelet count of blood obtained from abdominal aorta was determined and tissue samples from liver and lungs were collected to measure tissue PC and TNF-alpha mRNA expression
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| 520 |
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|a RESULTS: PC gene expression levels in lung tissues were significantly lowered (all P<0.01), but they were dramatically raised by Xuebijing injection during 8-72 hours post-CLP (all P<0.01). Compared with normal group, TNF-alpha mRNA levels in liver and lungs were significantly elevated at 2 hours post-CLP (P<0.05 or P<0.01). However, treatment with Xuebijing injection markedly reduced TNF-alpha mRNA both in liver and lungs at 2-24 hours (P<0.05 or P<0.01). In CLP group, blood platelet count was significantly decreased to certain extent at different intervals within 8-72 hours, and it was markedly elevated in the Xuebijing-treated group (P<0.05 or P<0.01)
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|a CONCLUSION: The current study suggests that Xuebijing injection could exert preventing effect on the development of severe sepsis by suppressing PC and TNF-alpha mRNA
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4 |
|a English Abstract
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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7 |
|a Drugs, Chinese Herbal
|2 NLM
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| 650 |
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7 |
|a Protein C
|2 NLM
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| 650 |
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7 |
|a RNA, Messenger
|2 NLM
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| 650 |
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7 |
|a Tumor Necrosis Factor-alpha
|2 NLM
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| 700 |
1 |
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|a Qiao, You-jie
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wu, Zi-xia
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Qian, Fang-fang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yao, Yong-ming
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yu, Yan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wu, Yao
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue
|d 1998
|g 19(2007), 8 vom: 21. Aug., Seite 488-91
|w (DE-627)NLM098227793
|x 1003-0603
|7 nnns
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| 773 |
1 |
8 |
|g volume:19
|g year:2007
|g number:8
|g day:21
|g month:08
|g pages:488-91
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| 912 |
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 19
|j 2007
|e 8
|b 21
|c 08
|h 488-91
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