Computational chemistry approach for the early detection of drug-induced idiosyncratic liver toxicity

Computational chemistry approach for the early detection of drug-induced idiosyncratic liver toxicity

Idiosyncratic drug toxicity (IDT), considered as a toxic host-dependent event, with an apparent lack of dose response relationship, is usually not predictable from early phases of clinical trials, representing a particularly confounding complication in drug development. Albeit a rare event (usually...

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Bibliographische Detailangaben
Veröffentlicht in:Journal of computational chemistry. - 1984. - 29(2008), 4 vom: 15. März, Seite 533-49
1. Verfasser: Cruz-Monteagudo, Maykel (VerfasserIn)
Weitere Verfasser: Cordeiro, M Natália D S, Borges, Fernanda
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2008
Zugriff auf das übergeordnete Werk:Journal of computational chemistry
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Pharmaceutical Preparations