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231223s2007 xx ||||| 00| ||eng c |
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|a pubmed24n0573.xml
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|a (DE-627)NLM17176482X
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|a (NLM)17661433
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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1 |
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|a Malon, Michal
|e verfasserin
|4 aut
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|a H(C)P and H(P)C triple-resonance experiments at natural abundance employing long-range couplings
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|c 2007
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|a Text
|b txt
|2 rdacontent
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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|a Band
|b nc
|2 rdacarrier
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|a Date Completed 12.10.2007
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|a Date Revised 06.08.2007
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|a published: Print
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|a Citation Status MEDLINE
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|a Modified two-dimensional (2D) triple-resonance H(C)P and H(P)C experiments based on INEPT/HMQC and double-INEPT schemes are applied to the study of organophosphorus compounds at natural abundances. The implementation of effective (1)H--(13)C gradient selection, additional purging pulsed field gradients, spinlock pulses, and improved phase cycling is demonstrated to allow weak correlation signals based on long-range couplings to be readily observed. Through the combination of two heteronuclear long-range coupling constants, (n)J(CH) and (n)J(PC) in H(C)P experiments or (n)J(PH) and (n)J(PC) in H(P)C experiments, protons can be correlated to a second heteronucleus through 4-7 chemical bonds. These experiments thus overcome the inherit limitations of classical (1)H-X HMBC experiments, which require a nonzero value of the heteronuclear coupling constant (n)J(XH). Ultra-broadband inversion composite pulses are successfully employed in the H(P)C INEPT/HMQC and H(P)C double-INEPT pulse sequences to increase the utility of the experiments and the quality of obtained spectra. This work extends and completes a set of 2D phase-sensitive triple-resonance experiments applicable at natural abundances, and also offers insight into the methodology of triple-resonance experiments and the application of pulsed field gradients. A one-dimensional triple-resonance experiment employing carbon detection is suggested for accurate determination of small (n)J(PC)
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Indicators and Reagents
|2 NLM
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| 650 |
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|a Organophosphorus Compounds
|2 NLM
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| 700 |
1 |
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|a Koshino, Hiroyuki
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Magnetic resonance in chemistry : MRC
|d 1985
|g 45(2007), 9 vom: 15. Sept., Seite 770-6
|w (DE-627)NLM098179667
|x 1097-458X
|7 nnns
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| 773 |
1 |
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|g volume:45
|g year:2007
|g number:9
|g day:15
|g month:09
|g pages:770-6
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|a AR
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|d 45
|j 2007
|e 9
|b 15
|c 09
|h 770-6
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