Interleukin-15 selectively expands CD57+ CD28- CD4+ T cells, which are increased in active rheumatoid arthritis

Interleukin-15 selectively expands CD57+ CD28- CD4+ T cells, which are increased in active rheumatoid arthritis

Proinflammatory cytokines as well as CD4(+) T cells play critical roles in the pathogenesis of rheumatoid arthritis (RA). Recently, an increase of CD57(+) or CD28(-)CD4(+) T cells was demonstrated in RA, although the mechanism of the increase of these T cells is unclear. In this study, we first exam...

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Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 124(2007), 3 vom: 04. Sept., Seite 328-35
1. Verfasser: Yamada, Hisakata (VerfasserIn)
Weitere Verfasser: Kaibara, Nobutaka, Okano, Shinji, Maeda, Takeshi, Shuto, Toshihide, Nakashima, Yasuharu, Okazaki, Ken, Iwamoto, Yukihide
Format: Aufsatz
Sprache:English
Veröffentlicht: 2007
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't CD28 Antigens CD57 Antigens Interleukin-15 Tumor Necrosis Factor-alpha