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231223s2007 xx ||||| 00| ||eng c |
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|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Stoodley, Robin
|e verfasserin
|4 aut
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|a Fluorescence of amphotericin B-deoxycholate (fungizone) monomers and aggregates and the effect of heat-treatment
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| 264 |
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|c 2007
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|a Text
|b txt
|2 rdacontent
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|a ohne Hilfsmittel zu benutzen
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|a Date Completed 17.09.2007
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|a Date Revised 21.11.2013
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Fluorescence excitation and emission spectra are reported for the polyene macrolide antifungal agent Amphotericin B formulated as micellar dispersion Fungizone (FZ) and its modified counterpart heat-treated Fungizone. The addition of sodium dodecyl sulfate or sodium deoxycholate surfactant to modulate the aggregation state of Amphotericin B confirms that the monomer and dimer states have different fluorescence spectra. Energy transfer from excited dimer to monomer is observed. Both FZ and heat-treated FZ (HTFZ) show expected S1 --> S0 fluorescence emission as well as anti-Kasha fluorescence emission from the S2 state. The excitation and S1 --> S0 emission spectra of HTFZ are similar to those of FZ, while the S2 --> S0 fluorescence differs in intensity between them. The variation in the rate constant for internal conversion from S2 to S1 as the surfactant concentration is increased differs for FZ and HTFZ; we propose that this may form a new basis for examining the super-aggregated character of AmB preparations. FZ and HTFZ have a similar stability to disaggregation by added sodium dodecyl sulfate surfactant. These findings provide the groundwork for future fluorescence characterization of FZ or HTFZ interactions with cell membranes
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Drug Combinations
|2 NLM
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|a Deoxycholic Acid
|2 NLM
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|a 005990WHZZ
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|a Amphotericin B
|2 NLM
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|a amphotericin B, deoxycholate drug combination
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|a Wasan, Kishor M
|e verfasserin
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|a Bizzotto, Dan
|e verfasserin
|4 aut
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1991
|g 23(2007), 17 vom: 14. Aug., Seite 8718-25
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|x 0743-7463
|7 nnns
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|g volume:23
|g year:2007
|g number:17
|g day:14
|g month:08
|g pages:8718-25
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