Toward the development of multi-epitope p53 cancer vaccines an in vitro assessment of CD8(+) T cell responses to HLA class I-restricted wild-type sequence p53 peptides

Toward the development of multi-epitope p53 cancer vaccines : an in vitro assessment of CD8(+) T cell responses to HLA class I-restricted wild-type sequence p53 peptides

Wild-type sequence (wt) p53 peptides are attractive candidates for broadly applicable cancer vaccines. Six HLA-A2 or HLA-A24-restricted wt p53 peptides were evaluated for their ex vivo immunogenicity and their potential for use in cancer vaccines. Peripheral blood mononuclear cells (PBMC) obtained f...

Ausführliche Beschreibung

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 125(2007), 1 vom: 01. Okt., Seite 43-51
1. Verfasser: Sakakura, Koichi (VerfasserIn)
Weitere Verfasser: Chikamatsu, Kazuaki, Furuya, Nobuhiko, Appella, Ettore, Whiteside, Theresa L, Deleo, Albert B
Format: Aufsatz
Sprache:English
Veröffentlicht: 2007
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Cancer Vaccines Epitopes, T-Lymphocyte Histocompatibility Antigens Class I Peptide Fragments Tumor Suppressor Protein p53