Mechanisms of PDL1-mediated regulation of autoimmune diabetes

Mechanisms of PDL1-mediated regulation of autoimmune diabetes

The PD-1-PDL1 pathway plays a critical role in regulating autoimmune diabetes as blockade or deficiency of PD-1 or PDL1 results in accelerated disease in NOD mice. We explored the cellular mechanisms involved in the regulation of these autoimmune responses by investigations involving various gene-de...

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Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 125(2007), 1 vom: 04. Okt., Seite 16-25
1. Verfasser: Guleria, Indira (VerfasserIn)
Weitere Verfasser: Gubbels Bupp, Melanie, Dada, Shirine, Fife, Brian, Tang, Qizhi, Ansari, Mohammed Javeed, Trikudanathan, Subbulaxmi, Vadivel, Nidyanandh, Fiorina, Paolo, Yagita, Hideo, Azuma, Miyuki, Atkinson, Mark, Bluestone, Jeffrey A, Sayegh, Mohamed H
Format: Aufsatz
Sprache:English
Veröffentlicht: 2007
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't B7-1 Antigen B7-H1 Antigen Cd274 protein, mouse Membrane Glycoproteins Peptides