(1)H and (13)C NMR signal assignments of paecilin A and B, two new chromone derivatives from mangrove endophytic fungus Paecilomyces sp. (tree 1-7)

(1)H and (13)C NMR signal assignments of paecilin A and B, two new chromone derivatives from mangrove endophytic fungus Paecilomyces sp. (tree 1-7)

Two new natural products, named paecilin A (1) and B (2), together with two known compounds secalonic acid D (3) and (11)-cytochalasa-6(12),13-diene-1,21-dione-16,18-dimethyl-7-hydroxy-10-phenyl-(7S*,13E,16S*,18S*) (4), were isolated from the mangrove endophytic fungus, Paecilomyces sp. (tree 1-7) f...

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Veröffentlicht in:Magnetic resonance in chemistry : MRC. - 1985. - 45(2007), 9 vom: 01. Sept., Seite 777-80
1. Verfasser: Guo, Zhiyong (VerfasserIn)
Weitere Verfasser: She, Zhigang, Shao, Changlun, Wen, Lu, Liu, Fan, Zheng, Zhonghui, Lin, Yongcheng
Format: Aufsatz
Sprache:English
Veröffentlicht: 2007
Zugriff auf das übergeordnete Werk:Magnetic resonance in chemistry : MRC
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Benzopyrans Enzyme Inhibitors Lactones Topoisomerase I Inhibitors Xanthones paecilin A paecilin B secalonic acid 56283-72-8
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245 1 0 |a (1)H and (13)C NMR signal assignments of paecilin A and B, two new chromone derivatives from mangrove endophytic fungus Paecilomyces sp. (tree 1-7) 
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520 |a Two new natural products, named paecilin A (1) and B (2), together with two known compounds secalonic acid D (3) and (11)-cytochalasa-6(12),13-diene-1,21-dione-16,18-dimethyl-7-hydroxy-10-phenyl-(7S*,13E,16S*,18S*) (4), were isolated from the mangrove endophytic fungus, Paecilomyces sp. (tree 1-7) from the South China Sea. 1D and 2D NMR experiments including COSY, HMQC, and HMBC were used for the determination of their structures. In our cytotoxicity assays, secalonic D (3) showed cytotoxicity toward KB cells with IC(50) < 1 microg ml(-1) and inhibiting human topoisomerase I with IC(50) at 0.16 micromol ml(-1). 1, 2, and 4 showed no activity to KB cells 
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700 1 |a She, Zhigang  |e verfasserin  |4 aut 
700 1 |a Shao, Changlun  |e verfasserin  |4 aut 
700 1 |a Wen, Lu  |e verfasserin  |4 aut 
700 1 |a Liu, Fan  |e verfasserin  |4 aut 
700 1 |a Zheng, Zhonghui  |e verfasserin  |4 aut 
700 1 |a Lin, Yongcheng  |e verfasserin  |4 aut 
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