|
|
|
|
| LEADER |
01000naa a22002652 4500 |
| 001 |
NLM171062493 |
| 003 |
DE-627 |
| 005 |
20231223124852.0 |
| 007 |
cr uuu---uuuuu |
| 008 |
231223s2007 xx |||||o 00| ||eng c |
| 024 |
7 |
|
|a 10.1111/j.1469-8137.2007.02109.x
|2 doi
|
| 028 |
5 |
2 |
|a pubmed24n0570.xml
|
| 035 |
|
|
|a (DE-627)NLM171062493
|
| 035 |
|
|
|a (NLM)17587371
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a eng
|
| 100 |
1 |
|
|a Zhao, Jian
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a Reactive oxygen species, nitric oxide, and their interactions play different roles in Cupressus lusitanica cell death and phytoalexin biosynthesis
|
| 264 |
|
1 |
|c 2007
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ƒaComputermedien
|b c
|2 rdamedia
|
| 338 |
|
|
|a ƒa Online-Ressource
|b cr
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 23.08.2007
|
| 500 |
|
|
|a Date Revised 07.12.2022
|
| 500 |
|
|
|a published: Print
|
| 500 |
|
|
|a Citation Status MEDLINE
|
| 520 |
|
|
|a Beta-thujaplicin Is a natural troponoid with strong antifungal, antiviral, and anticancer activities. Beta-thujaplicin production in yeast elicitor-treated Cupressus lusitanica cell culture and its relationships with reactive oxygen species (ROS) and nitric oxide (NO) production and hypersensitive cell death were investigated. Superoxide anion radical (O2*-) induced cell death and inhibited beta-thujaplicin accumulation, whereas hydrogen peroxide (H2O2) induced beta-thujaplicin accumulation but did not significantly affect cell death. Both elicitor and O2*- induced programmed cell death, which can be blocked by protease inhibitors, protein kinase inhibitors, and Ca2+ chelators. Elicitor-induced NO generation was nitric oxide synthase (NOS)-dependent. Inhibition of NO generation by NOS inhibitors and NO scavenger partly blocked the elicitor-induced beta-thujaplicin accumulation and cell death, and NO donors strongly induced cell death. Interaction among NO, H2O2, and O2*- shows that NO production and H2O2 production are interdependent, but NO and O2*- accumulation were negatively related because of coconsumption of NO and O2*-. NO- and O2*- -induced cell death required each other, and both were required for elicitor-induced cell death. A direct interaction between NO and O2*- was implicated in the production of a potent oxidant peroxynitrite, which might mediate the elicitor-induced cell death
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
4 |
|a Research Support, Non-U.S. Gov't
|
| 650 |
|
7 |
|a Monoterpenes
|2 NLM
|
| 650 |
|
7 |
|a Reactive Oxygen Species
|2 NLM
|
| 650 |
|
7 |
|a Sesquiterpenes
|2 NLM
|
| 650 |
|
7 |
|a Terpenes
|2 NLM
|
| 650 |
|
7 |
|a Nitric Oxide
|2 NLM
|
| 650 |
|
7 |
|a 31C4KY9ESH
|2 NLM
|
| 650 |
|
7 |
|a Tropolone
|2 NLM
|
| 650 |
|
7 |
|a 7L6DL16P1T
|2 NLM
|
| 650 |
|
7 |
|a Hydrogen Peroxide
|2 NLM
|
| 650 |
|
7 |
|a BBX060AN9V
|2 NLM
|
| 650 |
|
7 |
|a Nitric Oxide Synthase
|2 NLM
|
| 650 |
|
7 |
|a EC 1.14.13.39
|2 NLM
|
| 650 |
|
7 |
|a beta-thujaplicin
|2 NLM
|
| 650 |
|
7 |
|a U5335D6EBI
|2 NLM
|
| 650 |
|
7 |
|a Phytoalexins
|2 NLM
|
| 700 |
1 |
|
|a Fujita, Koki
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Sakai, Kokki
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t The New phytologist
|d 1979
|g 175(2007), 2 vom: 01., Seite 215-229
|w (DE-627)NLM09818248X
|x 1469-8137
|7 nnns
|
| 773 |
1 |
8 |
|g volume:175
|g year:2007
|g number:2
|g day:01
|g pages:215-229
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.1111/j.1469-8137.2007.02109.x
|3 Volltext
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_350
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 175
|j 2007
|e 2
|b 01
|h 215-229
|