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231223s2007 xx ||||| 00| ||eng c |
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|a pubmed25n0570.xml
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|a (DE-627)NLM171048105
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|a (NLM)17585789
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|a DE-627
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|e rakwb
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|a eng
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| 100 |
1 |
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|a Sandison, Mairi E
|e verfasserin
|4 aut
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| 245 |
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|a Air-exposure technique for the formation of artificial lipid bilayers in microsystems
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| 264 |
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|c 2007
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 24.10.2007
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|a Date Revised 10.07.2007
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a To develop a reliable method for on-chip bilayer lipid membrane (BLM) formation, which could be employed for use in a biosensor array platform, a polymer microfluidic device has been constructed, and the formation of suspended BLMs within it has been investigated. A simple, yet reproducible BLM formation protocol has been developed, in which a brief air-exposure period is employed to induce the rapid thinning of an initially thick lipid-solvent layer. The technique is rapid, reproducible, and amenable to the simple injection of proteins or analytes, as well as to buffer exchange on both sides of the membrane. Scaling up the technique for use in an array platform is also straightforward, the simultaneous formation of three individually addressable BLMs being demonstrated
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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| 650 |
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|a Lipid Bilayers
|2 NLM
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| 700 |
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|a Zagnoni, Michele
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Morgan, Hywel
|e verfasserin
|4 aut
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| 773 |
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8 |
|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1985
|g 23(2007), 15 vom: 17. Juli, Seite 8277-84
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnas
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| 773 |
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|g volume:23
|g year:2007
|g number:15
|g day:17
|g month:07
|g pages:8277-84
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|a AR
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|d 23
|j 2007
|e 15
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|c 07
|h 8277-84
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