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01000caa a22002652 4500 |
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NLM170968537 |
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DE-627 |
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20250208100012.0 |
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tu |
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231223s2007 xx ||||| 00| ||chi c |
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5 |
2 |
|a pubmed25n0570.xml
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| 035 |
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|a (DE-627)NLM170968537
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| 035 |
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|a (NLM)17577447
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a chi
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| 100 |
1 |
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|a Li, Yin-ping
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Effects of Xuebijing injection on thrombomodulin and endothelial cell protein C receptor in septic rats
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| 264 |
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1 |
|c 2007
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 09.07.2009
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| 500 |
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|a Date Revised 19.06.2007
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|a published: Print
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|a Citation Status MEDLINE
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| 520 |
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|a OBJECTIVE: To investigate effects of the integrated traditional Chinese medicine Xuebijing injection on thrombomodulin (TM) and endothelial cell protein C receptor (EPCR) in septic rats
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| 520 |
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|a METHODS: Ninety-six healthy Wistar rats were randomly divided into four groups: control group, sham operation group, cecal ligation and puncture (CLP) model group, and Xuebijing-treated group. Sepsis was reproduced by CLP. The two latter groups were divided into five subgroups of 2, 8, 24, 48 and 72-hour with 8 rats in each subgroup. Tissue samples from liver and lung were collected to determine tissue TM and EPCR mRNA expression
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| 520 |
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|a RESULTS: TM and EPCR mRNA expressions were observed in liver and lung in control group and sham operation group, while with no significant differences at 2 hours post-CLP (both P>0.05). TM and EPCR gene expression levels in tissues were significantly increased to certain extent at 8-48 hours (all P<0.01), and were dramatically decreased following Xuebijing injection at 72 hours post-CLP (both P>0.05). Also, treatment with Xuebijing injection markedly decreased TM and EPCR mRNA levels to certain extents at 8 and 24 hours, and markedly increased at 48 and 72 hours compared with those of model group
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| 520 |
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|a CONCLUSION: These data suggest that Xuebijing injection could raise TM and EPCR mRNA expression, thereby it might be effective in prevention of development of severe sepsis
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| 650 |
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4 |
|a English Abstract
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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7 |
|a Blood Coagulation Factors
|2 NLM
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| 650 |
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7 |
|a Drugs, Chinese Herbal
|2 NLM
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| 650 |
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7 |
|a RNA, Messenger
|2 NLM
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| 650 |
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7 |
|a Receptors, Cell Surface
|2 NLM
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| 650 |
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7 |
|a Thrombomodulin
|2 NLM
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| 650 |
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7 |
|a activated protein C receptor
|2 NLM
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| 700 |
1 |
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|a Qiao, You-jie
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wu, Zi-xia
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Qian, Fang-fang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yao, Yong-ming
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yu, Yan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wu, Yao
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue
|d 1998
|g 19(2007), 6 vom: 18. Juni, Seite 365-8
|w (DE-627)NLM098227793
|x 1003-0603
|7 nnns
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| 773 |
1 |
8 |
|g volume:19
|g year:2007
|g number:6
|g day:18
|g month:06
|g pages:365-8
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| 912 |
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 19
|j 2007
|e 6
|b 18
|c 06
|h 365-8
|