Study on expression of matrix metalloproteinase-2 and matrix metalloproteinase-9 in brain tissue adjacent to hemorrhage after brain hemorrhage in human

OBJECTIVE: To investigate the expression and significance of matrix metalloproteinase-2 (MMP-2) and MMP-9 in peri-hematoma brain tissues after acute brain hemorrhage in human

Bibliographische Detailangaben
Veröffentlicht in:Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue. - 1998. - 19(2007), 6 vom: 18. Juni, Seite 336-9
1. Verfasser: Ke, Shao-fa (VerfasserIn)
Weitere Verfasser: Jin, Xiao-ping, Zhang, Ke-hao, Wang, Jun-xing, Hu, Xiao-ming, Zhang, Dan-hong, Chen, Qiu-yue, Zhou, Yuan-lin
Format: Aufsatz
Sprache:Chinese
Veröffentlicht: 2007
Zugriff auf das übergeordnete Werk:Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue
Schlagworte:English Abstract Journal Article Research Support, Non-U.S. Gov't MMP2 protein, human EC 3.4.24.24 Matrix Metalloproteinase 2 Matrix Metalloproteinase 9 EC 3.4.24.35
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245 1 0 |a Study on expression of matrix metalloproteinase-2 and matrix metalloproteinase-9 in brain tissue adjacent to hemorrhage after brain hemorrhage in human 
264 1 |c 2007 
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500 |a Date Revised 19.06.2007 
500 |a published: Print 
500 |a Citation Status MEDLINE 
520 |a OBJECTIVE: To investigate the expression and significance of matrix metalloproteinase-2 (MMP-2) and MMP-9 in peri-hematoma brain tissues after acute brain hemorrhage in human 
520 |a METHODS: Forty-two patients with acute brain hemorrhage received surgery, the brain tissues adjacent to hemorrhagic site were obtained during surgery, and positive expressions of MMP-2 and MMP-9 were determined with immunohistochemical staining. Brain tissues from 30 patients with cerebral trauma were obtained to serve as controls 
520 |a RESULTS: The positive expressions of MMP-2 and MMP-9 in focal brain tissues were significantly elevated in early acute brain hemorrhage. Compared with 28 and 27 cases with MMP-2 and MMP-9 positive expression respectively in control group, there were 39 and 37 cases with MMP-2 and MMP-9 positive expression respectively in acute brain hemorrhage group. There were no significant differences between two groups (both P>0.05) 
520 |a CONCLUSION: MMP-2 and MMP-9 might contribute to brain edema formation in the acute intra-cerebral hemorrhage of human 
650 4 |a English Abstract 
650 4 |a Journal Article 
650 4 |a Research Support, Non-U.S. Gov't 
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650 7 |a EC 3.4.24.24  |2 NLM 
650 7 |a Matrix Metalloproteinase 2  |2 NLM 
650 7 |a EC 3.4.24.24  |2 NLM 
650 7 |a Matrix Metalloproteinase 9  |2 NLM 
650 7 |a EC 3.4.24.35  |2 NLM 
700 1 |a Jin, Xiao-ping  |e verfasserin  |4 aut 
700 1 |a Zhang, Ke-hao  |e verfasserin  |4 aut 
700 1 |a Wang, Jun-xing  |e verfasserin  |4 aut 
700 1 |a Hu, Xiao-ming  |e verfasserin  |4 aut 
700 1 |a Zhang, Dan-hong  |e verfasserin  |4 aut 
700 1 |a Chen, Qiu-yue  |e verfasserin  |4 aut 
700 1 |a Zhou, Yuan-lin  |e verfasserin  |4 aut 
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773 1 8 |g volume:19  |g year:2007  |g number:6  |g day:18  |g month:06  |g pages:336-9 
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