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|a pubmed25n0570.xml
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|a (DE-627)NLM17096843X
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|a (NLM)17577436
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a chi
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|a Cui, Na
|e verfasserin
|4 aut
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|a Early changes in function of hypothalamic-pituitary-target gland axis in patients with severe sepsis and septic shock
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|c 2007
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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|a Band
|b nc
|2 rdacarrier
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|a Date Completed 09.07.2009
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|a Date Revised 11.03.2022
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|a published: Print
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|a Citation Status MEDLINE
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|a OBJECTIVE: To investigate the early changes in function of hypothalamic-pituitary-target gland (HPTG) axis in patients with severe sepsis and septic shock, in order to clarify its relationship with severity and prognosis of the patients
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|a METHODS: The serum contents of cortisol (F), triiodothyronine (T(3)), thyroxine (T(4)), thyrotropic-stimulating hormone (TSH), growth hormone (GH), follicle-stimulating hormone (FSH), luteotropic hormone (LH), prolactin (PRL) and plasma concentration of adrenocorticotrophic hormone (ACTH) in 10 severe sepsis and 12 septic shock patients on day 1, 3, 5 after diagnosis was made, and 12 patients with no infection or septic shock served as controls. The hypothalamic-pituitary adrenal gland axis (HPAA) function of the patients with severe sepsis and septic shock were evaluated with 1 microgram ACTH stimulation test given 1 day after the concentrations of the above hormones were determined
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|a RESULTS: Compared with the control patients, ACTH, T(3), T(4), GH, FSH, LH and PRL levels were significantly changed in patients with severe sepsis and septic shock (P<0.05 or P<0.01). The numbers of patients with reaction to 1 microgram ACTH stimulation test were similar between patients with severe sepsis (6 cases non-reaction and 3 cases reaction) and patients with septic shock (9 cases non reaction and 2 cases reaction, P>0.05). According to the acute physiology and chronic health evaluation II (APACHE II) and sepsis-related organ failure assessment (SOFA) score, changes in ACTH, T(3), T(4), GH and PRL levels were closely related to the severity of illness (P<0.05 or P<0.01). Significant differences were found in ACTH, T(3), T(4) levels between survivors and non-survivors (P<0.05 or P<0.01). ACTH, T(4) levels and SOFA score were independent predictors of the 28-day hospital mortality (P<0.05 or P<0.01)
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|a CONCLUSION: The early changes in HPTG axis are closely related with the severity and hospital mortality in patients with severe sepsis and septic shock
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|a English Abstract
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Hormones
|2 NLM
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|a Liu, Da-wei
|e verfasserin
|4 aut
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|a Wang, Hao
|e verfasserin
|4 aut
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|a Zeng, Zheng-pei
|e verfasserin
|4 aut
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| 700 |
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|a Long, Yun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chai, Wen-zhao
|e verfasserin
|4 aut
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| 700 |
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|a Liu, Hong-zhong
|e verfasserin
|4 aut
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| 700 |
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|a Wang, Xiao-ting
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue
|d 1998
|g 19(2007), 6 vom: 18. Juni, Seite 332-5
|w (DE-627)NLM098227793
|x 1003-0603
|7 nnns
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| 773 |
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|g volume:19
|g year:2007
|g number:6
|g day:18
|g month:06
|g pages:332-5
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|a GBV_USEFLAG_A
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|a SYSFLAG_A
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|a GBV_NLM
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|a GBV_ILN_350
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|a AR
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|d 19
|j 2007
|e 6
|b 18
|c 06
|h 332-5
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