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DE-627 |
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20231223124325.0 |
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231223s2007 xx ||||| 00| ||eng c |
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|a pubmed24n0569.xml
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|a (DE-627)NLM170810615
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|a (NLM)17560831
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Clavel, Gaëlle
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Angiogenesis markers (VEGF, soluble receptor of VEGF and angiopoietin-1) in very early arthritis and their association with inflammation and joint destruction
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| 264 |
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1 |
|c 2007
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 18.09.2007
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|a Date Revised 24.11.2016
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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| 520 |
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|a OBJECTIVE: To investigate the involvement of angiogenesis markers in very early arthritis patients and their relevance to predict further joint destruction
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| 520 |
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|a METHODS: Levels of Vascular Endothelial Growth Factor (VEGF), angiopoietin-1 (Ang-1), and soluble Fms-like tyrosine kinase-1 (sFlt-1) were measured by ELISA in serum samples from 310 patients having polyarthritis, evolving for less than 6 months (VErA cohort). Each angiogenesis marker was measured at baseline and one year later. X-rays of hands and feet were carried out at inclusion and after 1 year and read using the van der Heidje-modified Sharp method
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| 520 |
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|a RESULTS: At baseline and after 1 year, VEGF levels were correlated with clinical and biological parameters of inflammation. We also observed a positive correlation between sFlt-1 levels and biological inflammation (Erythrocyte Sedimentation Rate (ESR): r=0.17, p=0.006; C Reactive Protein: r=0.14, p=0.02). Angiopoietin-1 levels were correlated with ESR (r=0.12, p=0.04). Interestingly, only VEGF levels measured at baseline were correlated with Disease Activity Score measured 1 year later. Relationship between angiogenesis markers and radiographic progression was also evaluated. VEGF and Ang-1 levels measured at inclusion were related with Sharp score after one year (VEGF: r=0.21, p<0.001; Ang-1: r=0.24, p<0.001; Spearman's test). Moreover, VEGF levels were higher in patients with radiographic progression (p=0.002)
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|a CONCLUSION: Serum concentrations of VEGF, sFlt-1 and angiopoietin-1 were correlated to parameters of inflammation and to bone destruction in early arthritis. These results contribute to demonstrate that angiogenesis reflects disease severity and angiogenesis markers might become a new useful tool to evaluate disease activity and to estimate outcome for patients with inflammatory arthritis
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|a Journal Article
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|a Multicenter Study
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| 650 |
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|a Research Support, Non-U.S. Gov't
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| 650 |
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7 |
|a Angiopoietin-1
|2 NLM
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| 650 |
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7 |
|a Vascular Endothelial Growth Factor A
|2 NLM
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| 650 |
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7 |
|a FLT1 protein, human
|2 NLM
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| 650 |
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7 |
|a EC 2.7.10.1
|2 NLM
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| 650 |
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7 |
|a Receptors, Vascular Endothelial Growth Factor
|2 NLM
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| 650 |
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7 |
|a EC 2.7.10.1
|2 NLM
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| 650 |
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7 |
|a Vascular Endothelial Growth Factor Receptor-1
|2 NLM
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| 650 |
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7 |
|a EC 2.7.10.1
|2 NLM
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| 700 |
1 |
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|a Bessis, Natacha
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lemeiter, Delphine
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Fardellone, Patrice
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Mejjad, Othmane
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ménard, Jean-Francois
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Pouplin, Sophie
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Boumier, Patrick
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Vittecoq, Olivier
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Le Loët, Xavier
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Boissier, Marie-Christophe
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 124(2007), 2 vom: 27. Aug., Seite 158-64
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:124
|g year:2007
|g number:2
|g day:27
|g month:08
|g pages:158-64
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| 912 |
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_11
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| 912 |
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|a GBV_ILN_24
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 124
|j 2007
|e 2
|b 27
|c 08
|h 158-64
|