Structure elucidation of thermal degradation products of amlodipine

Copyright 2007 John Wiley & Sons, Ltd.

Bibliographische Detailangaben
Veröffentlicht in:Magnetic resonance in chemistry : MRC. - 1985. - 45(2007), 8 vom: 01. Aug., Seite 688-91
1. Verfasser: Lakshmi Devi, A Siva (VerfasserIn)
Weitere Verfasser: Srinivasa Rao, Y, Satish, M, Jyothi, G, Babu Rao, K, Omdutt, T
Format: Aufsatz
Sprache:English
Veröffentlicht: 2007
Zugriff auf das übergeordnete Werk:Magnetic resonance in chemistry : MRC
Schlagworte:Journal Article Amlodipine 1J444QC288
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520 |a Thermal degradation of amlodipine base causes intramolecular reactions affording three cyclic products, referred to as AMLDEG-I, AMLDEG-II, and AMLDEG-III, respectively. AMLDEG-I is a cyclized product formed by intramolecular elimination of ammonia from amlodipine. AMLDEG-II is a positional isomer of AMLDEG-I. AMLDEG-III is also intramolecular cyclisation product. The three degradation products were isolated by column chromatography and characterized by FT-IR and 1H and 13C NMR spectroscopy data. The AMLDEG-III was crystallized and its structure was solved by single crystal X-ray diffraction (SXRD) 
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700 1 |a Babu Rao, K  |e verfasserin  |4 aut 
700 1 |a Omdutt, T  |e verfasserin  |4 aut 
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