Inflammation and bone erosion are suppressed in models of rheumatoid arthritis following treatment with a novel Syk inhibitor
Spleen tyrosine kinase (Syk), a key mediator of immunoreceptor signaling in inflammatory cells, is essential for immune complex-mediated signal transduction initiated by activated receptors for immunoglobulin G. In collagen-induced arthritis, R788/R406, a novel and potent small molecule Syk inhibito...
| Publié dans: | Clinical immunology (Orlando, Fla.). - 1999. - 124(2007), 3 vom: 28. Sept., Seite 244-57 |
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| Auteur principal: | |
| Autres auteurs: | , , , , , , , , |
| Format: | Article |
| Langue: | English |
| Publié: |
2007
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| Accès à la collection: | Clinical immunology (Orlando, Fla.) |
| Sujets: | Journal Article Aminopyridines Collagen Type II Immunoglobulin G Intracellular Signaling Peptides and Proteins Morpholines N4-(2,2-dimethyl-3-oxo-4H-pyrid(1,4)oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine Oxazines Prodrugs Pyridines plus... |