Inflammation and bone erosion are suppressed in models of rheumatoid arthritis following treatment with a novel Syk inhibitor

Inflammation and bone erosion are suppressed in models of rheumatoid arthritis following treatment with a novel Syk inhibitor

Spleen tyrosine kinase (Syk), a key mediator of immunoreceptor signaling in inflammatory cells, is essential for immune complex-mediated signal transduction initiated by activated receptors for immunoglobulin G. In collagen-induced arthritis, R788/R406, a novel and potent small molecule Syk inhibito...

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Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 124(2007), 3 vom: 28. Sept., Seite 244-57
1. Verfasser: Pine, Polly R (VerfasserIn)
Weitere Verfasser: Chang, Betty, Schoettler, Nathan, Banquerigo, Mona L, Wang, Su, Lau, Angela, Zhao, Feifei, Grossbard, Elliott B, Payan, Donald G, Brahn, Ernest
Format: Aufsatz
Sprache:English
Veröffentlicht: 2007
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Aminopyridines Collagen Type II Immunoglobulin G Intracellular Signaling Peptides and Proteins Morpholines N4-(2,2-dimethyl-3-oxo-4H-pyrid(1,4)oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine Oxazines Prodrugs Pyridines mehr... Pyrimidines Receptors, IgG Protein-Tyrosine Kinases EC 2.7.10.1 SYK protein, human EC 2.7.10.2 Syk Kinase Syk protein, rat fostamatinib SQ8A3S5101