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231223s2007 xx ||||| 00| ||eng c |
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|a pubmed24n0568.xml
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|a (DE-627)NLM170439585
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|a (NLM)17518486
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Zhao, Wenting
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Tunable stabilization of gold nanoparticles in aqueous solutions by mononucleotides
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| 264 |
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1 |
|c 2007
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 03.08.2007
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|a Date Revised 21.11.2008
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Gold nanoparticles are one of the popular nanomaterials, widely used in biosensor applications as well as nanostructure construction. An essential attribute of these gold nanoparticles (Au-nps) is their stabilization against salt-induced aggregation. In this work, utilization of deoxyribonucleotides (dNTPs) as a tunable surface-stabilization agent for Au-nps was investigated. It was found that surfaces of Au-nps are covered by a layer of dNTPs after an adequate incubation with dNTPs solutions. Electrostatic repulsion among dNTP-coated Au-nps could prevent aggregation of Au-nps at a high salt concentration. The strength of dNTP-based protection can be manipulated by changing preparation protocols (e.g., incubation temperature, ionic strength, and ratio of Au-nps to dNTPs). Four different types of dNTPs exhibit different binding affinity to Au-nps and thus various stabilization efficiency in the order of dATP > dCTP > dGTP approximately dTTP. Moreover, this salt-induced aggregation can be reinitiated by the increase of solution temperature, which leads to a partial removal of the protective dNTP layer on Au-nps. The advantage of thermally tunable aggregation/dispersion of Au-nps mediated by dNTP adsorption offers a useful approach for the preparation of biomolecule (oligonucleotides and oligopeptides) modified nanoparticles in applications of bioassay and nanobiotechnology
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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| 650 |
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|a Deoxyribonucleotides
|2 NLM
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| 650 |
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|a Gold
|2 NLM
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| 650 |
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|a 7440-57-5
|2 NLM
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| 700 |
1 |
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|a Lee, Thomas M H
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Leung, Sharon S Y
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hsing, I-Ming
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 23(2007), 13 vom: 19. Juni, Seite 7143-7
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
1 |
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|g volume:23
|g year:2007
|g number:13
|g day:19
|g month:06
|g pages:7143-7
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|d 23
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|e 13
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|h 7143-7
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