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01000naa a22002652 4500 |
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NLM170389588 |
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DE-627 |
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20231223123412.0 |
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231223s2007 xx ||||| 00| ||eng c |
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|a pubmed24n0568.xml
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|a (DE-627)NLM170389588
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|a (NLM)17513174
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Segat, Ludovica
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Association of polymorphisms in the first exon of mannose binding lectin gene (MBL2) in Brazilian patients with HCV infection
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| 264 |
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1 |
|c 2007
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 10.08.2007
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|a Date Revised 01.12.2018
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a In our study we investigated the role of the polymorphisms in the first exon of MBL2 gene in the susceptibility to HCV infection and disease progression in a Northeastern Brazilian population. One hundred and eleven patients seen at the Gastroenterology Service of the Oswaldo Cruz Hospital of the University of Pernambuco were included in this study. A total of 165 unexposed, uninfected individuals matched for place of origin were employed as healthy controls. MBL2 genotyping was performed by using a melting temperature assay. The 0 allele was significantly more frequent in the HCV positive group than the healthy controls (34% vs. 20%, p<0.01, respectively) and was associated to an increased risk of HCV-1 infection (O.R.=2.1; C.I. 1.41-3.19). Also genotypes frequencies were significantly different in HCV positive subjects when compared to healthy controls with the 00 and A0 genotypes being significantly overrepresented in HCV infected subject (15% and 37%, respectively) as compared to healthy subjects (6% and 27%, respectively, p<0.01 ) Allele and genotypes frequencies were also evaluated in HCV infected subjects according to their response to pegylated-INFalpha/riboviron therapy. There was a trend for HCV positive responders vs. non-responders to be 0 allele positive and a similar trend was observed for the MBL2 A0 and 00 genotypes, but neither of these reached statistical significance. Our findings indicate that MBL might represent an important antiviral molecule having a protective role in the first stages of HCV infection, as shown by the increased frequency of wild-type alleles in control population as compared to the infected group
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| 650 |
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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| 650 |
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7 |
|a Antiviral Agents
|2 NLM
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| 650 |
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7 |
|a Interferon alpha-2
|2 NLM
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| 650 |
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7 |
|a Interferon-alpha
|2 NLM
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| 650 |
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7 |
|a Mannose-Binding Lectin
|2 NLM
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| 650 |
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7 |
|a Recombinant Proteins
|2 NLM
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| 650 |
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7 |
|a Polyethylene Glycols
|2 NLM
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| 650 |
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7 |
|a 3WJQ0SDW1A
|2 NLM
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| 650 |
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7 |
|a Ribavirin
|2 NLM
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| 650 |
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7 |
|a 49717AWG6K
|2 NLM
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| 650 |
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7 |
|a peginterferon alfa-2b
|2 NLM
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| 650 |
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7 |
|a G8RGG88B68
|2 NLM
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| 700 |
1 |
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|a Silva Vasconcelos, Luydson Richardson
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Montenegro de Melo, Francisco
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Santos Silva, Bruna
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Arraes, Luiz Cláudio
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Moura, Patrícia
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Crovella, Sergio
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 124(2007), 1 vom: 15. Juli, Seite 13-7
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:124
|g year:2007
|g number:1
|g day:15
|g month:07
|g pages:13-7
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| 912 |
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_11
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| 912 |
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|a GBV_ILN_24
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 124
|j 2007
|e 1
|b 15
|c 07
|h 13-7
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