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01000naa a22002652 4500 |
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NLM170380882 |
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DE-627 |
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20231223123400.0 |
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tu |
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231223s2007 xx ||||| 00| ||eng c |
| 028 |
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|a pubmed24n0568.xml
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|a (DE-627)NLM170380882
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|a (NLM)17512253
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Han, Shu-fang
|e verfasserin
|4 aut
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| 245 |
1 |
4 |
|a The opposite-direction modulation of CD4+CD25+ Tregs and T helper 1 cells in acute coronary syndromes
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| 264 |
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1 |
|c 2007
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 10.08.2007
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|a Date Revised 08.04.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Different subsets of T lymphocytes have different functions in atherosclerosis advancement. T helper 1 cells and T regulatory 1 cells have been demonstrated to play opposite roles in rupture of atherosclerotic lesion. However, the role of novel subset of T regulatory cells, known as CD4+CD25+Foxp3+ T cells, remains largely unknown in coronary artery disease (CAD). In this study, we investigated the peripheral CD4+CD25+Foxp3+ T cells of patients with CAD and controls. The patients submitted were divided into three groups: stable angina pectoris (SA) group, unstable angina pectoris (UA) group and acute myocardial infarction (AMI) group. We analyzed the frequencies of peripheral CD4+CD25+Foxp3+ T cells and T helper 1/T helper 2 cells, expression of Foxp3 in CD4+CD25+ T subsets and cytokines pattern in patients and controls. We found that the reduction of CD4+CD25+Foxp3+ T lymphocytes was consistent with the expansion of Th1 cells in patients with unstable CAD. The reversed development between CD4+CD25+ Tregs and Th1 cells might contribute to plaque destabilization
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| 650 |
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|a Journal Article
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| 650 |
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7 |
|a Forkhead Transcription Factors
|2 NLM
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| 650 |
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|a Interleukin-2 Receptor alpha Subunit
|2 NLM
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| 700 |
1 |
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|a Liu, Peng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Wei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Bu, Lun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Shen, Min
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Hu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Fan, Yan-hong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Cheng, Kang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Cheng, He-xiang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Cheng-xiang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Jia, Guo-liang
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 124(2007), 1 vom: 31. Juli, Seite 90-7
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:124
|g year:2007
|g number:1
|g day:31
|g month:07
|g pages:90-7
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| 912 |
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| 912 |
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 124
|j 2007
|e 1
|b 31
|c 07
|h 90-7
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