Action profiles of statins and calcineurin inhibitors during human mixed lymphocyte reaction

Action profiles of statins and calcineurin inhibitors during human mixed lymphocyte reaction

The cell-to-cell interaction through binding intercellular adhesion molecule (ICAM)-1 and CD40 on monocytes and their ligands such as lymphocyte function-associated antigen (LFA)-1 and CD40 ligand (CD40L) on T-cells plays roles in cytokine production and T-cell proliferation. Interleukin (IL)-18, wh...

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Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 123(2007), 3 vom: 31. Juni, Seite 324-32
1. Verfasser: Takahashi, Hideo Kohka (VerfasserIn)
Weitere Verfasser: Iwagaki, Hiromi, Yagi, Takahito, Kanke, Toru, Liu, Keyue, Yoshino, Tadashi, Tanaka, Noriaki, Nishibori, Masahiro
Format: Aufsatz
Sprache:English
Veröffentlicht: 2007
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article CD40 Antigens Calcineurin Inhibitors Fatty Acids, Monounsaturated Hydroxymethylglutaryl-CoA Reductase Inhibitors Immunosuppressive Agents Indoles Interleukin-18 LFA 878 LFA703 mehr... Naphthalenes Oxazines Intercellular Adhesion Molecule-1 126547-89-5 Interleukin-12 187348-17-0 Fluvastatin 4L066368AS Interferon-gamma 82115-62-6 Cyclosporine 83HN0GTJ6D Hydroxymethylglutaryl CoA Reductases EC 1.1.1.- Pravastatin KXO2KT9N0G Mevalonic Acid S5UOB36OCZ Tacrolimus WM0HAQ4WNM
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100 1 |a Takahashi, Hideo Kohka  |e verfasserin  |4 aut 
245 1 0 |a Action profiles of statins and calcineurin inhibitors during human mixed lymphocyte reaction 
264 1 |c 2007 
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500 |a Date Completed 27.08.2007 
500 |a Date Revised 01.12.2018 
500 |a published: Print-Electronic 
500 |a Citation Status MEDLINE 
520 |a The cell-to-cell interaction through binding intercellular adhesion molecule (ICAM)-1 and CD40 on monocytes and their ligands such as lymphocyte function-associated antigen (LFA)-1 and CD40 ligand (CD40L) on T-cells plays roles in cytokine production and T-cell proliferation. Interleukin (IL)-18, which is elevated in the plasma during acute rejection after organ transplantation, induces the expression of ICAM-1 and CD40 on monocytes, the production of interferon (IFN)-gamma and IL-12 and the proliferation of T-cells during the human mixed lymphocyte reaction (MLR). In addition to the cholesterol lowering effect, statins improve patient survival and decrease rejection episodes in transplant recipients. In the present study, we investigated the difference of effect of statins and calcineurin inhibitors during MLR. 3-Hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductase inhibitors, fluvastatin and pravastatin and statin-derived LFA-1 inhibitors, LFA703 and LFA878, which did not inhibit HMG-CoA reductase, suppressed the production of IFN-gamma and IL-12 and the lymphocyte proliferation as well as the expression of ICAM-1 and CD40 on monocytes regardless of the presence of IL-18. However, the calcineurin inhibitors, tacrolimus and cyclosporine A (CsA), inhibited the IL-18-enhanced cytokine production and lymphocyte proliferation without any effect on the adhesion molecule expression. Thus, the action mechanism of stain is different from that of calcineurin inhibitors 
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650 7 |a Calcineurin Inhibitors  |2 NLM 
650 7 |a Fatty Acids, Monounsaturated  |2 NLM 
650 7 |a Hydroxymethylglutaryl-CoA Reductase Inhibitors  |2 NLM 
650 7 |a Immunosuppressive Agents  |2 NLM 
650 7 |a Indoles  |2 NLM 
650 7 |a Interleukin-18  |2 NLM 
650 7 |a LFA 878  |2 NLM 
650 7 |a LFA703  |2 NLM 
650 7 |a Naphthalenes  |2 NLM 
650 7 |a Oxazines  |2 NLM 
650 7 |a Intercellular Adhesion Molecule-1  |2 NLM 
650 7 |a 126547-89-5  |2 NLM 
650 7 |a Interleukin-12  |2 NLM 
650 7 |a 187348-17-0  |2 NLM 
650 7 |a Fluvastatin  |2 NLM 
650 7 |a 4L066368AS  |2 NLM 
650 7 |a Interferon-gamma  |2 NLM 
650 7 |a 82115-62-6  |2 NLM 
650 7 |a Cyclosporine  |2 NLM 
650 7 |a 83HN0GTJ6D  |2 NLM 
650 7 |a Hydroxymethylglutaryl CoA Reductases  |2 NLM 
650 7 |a EC 1.1.1.-  |2 NLM 
650 7 |a Pravastatin  |2 NLM 
650 7 |a KXO2KT9N0G  |2 NLM 
650 7 |a Mevalonic Acid  |2 NLM 
650 7 |a S5UOB36OCZ  |2 NLM 
650 7 |a Tacrolimus  |2 NLM 
650 7 |a WM0HAQ4WNM  |2 NLM 
700 1 |a Iwagaki, Hiromi  |e verfasserin  |4 aut 
700 1 |a Yagi, Takahito  |e verfasserin  |4 aut 
700 1 |a Kanke, Toru  |e verfasserin  |4 aut 
700 1 |a Liu, Keyue  |e verfasserin  |4 aut 
700 1 |a Yoshino, Tadashi  |e verfasserin  |4 aut 
700 1 |a Tanaka, Noriaki  |e verfasserin  |4 aut 
700 1 |a Nishibori, Masahiro  |e verfasserin  |4 aut 
773 0 8 |i Enthalten in  |t Clinical immunology (Orlando, Fla.)  |d 1999  |g 123(2007), 3 vom: 31. Juni, Seite 324-32  |w (DE-627)NLM098196855  |x 1521-7035  |7 nnns 
773 1 8 |g volume:123  |g year:2007  |g number:3  |g day:31  |g month:06  |g pages:324-32 
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