In vitro, ex vivo and in vivo immunopharmacological activities of the isoxazoline compound VGX-1027 modulation of cytokine synthesis and prevention of both organ-specific and systemic autoimmune diseases in murine models

In vitro, ex vivo and in vivo immunopharmacological activities of the isoxazoline compound VGX-1027 : modulation of cytokine synthesis and prevention of both organ-specific and systemic autoimmune diseases in murine models

We have presently studied the in vitro, ex vivo and in vivo immunopharmacological effects of VGX-1027 [(S,R)-3-phenyl-4,5-dihydro-5-isoxasole acetic acid]. This compound reduced the secretion of IL-1beta, TNF-alpha and IL-10 from purified murine macrophages stimulated "in vitro" with lipop...

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Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 123(2007), 3 vom: 01. Juni, Seite 311-23
1. Verfasser: Stojanovic, Ivana (VerfasserIn)
Weitere Verfasser: Cuzzocrea, Salvatore, Mangano, Katia, Mazzon, Emanuela, Miljkovic, Djordje, Wang, Mingjun, Donia, Marco, Al Abed, Yousef, Kim, Joseph, Nicoletti, Ferdinando, Stosic-Grujicic, Stanislava, Claesson, Mogens
Format: Aufsatz
Sprache:English
Veröffentlicht: 2007
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't 3-phenyl-4,5-dihydro-5-isoxazole acetic acid Acetates Cytokines I-kappa B Proteins Immunologic Factors Lipopolysaccharides Oxazoles Acetylmuramyl-Alanyl-Isoglutamine mehr... 53678-77-6 Mitogen-Activated Protein Kinases EC 2.7.11.24