DNA-based approach for interparticle interaction control

Micron-sized latex particles with single-stranded DNA grafted to the surface have been used as a model system to study DNA mediated interactions. A new approach of tuning the interactions between particles is proposed, which allows for a gradual change of the assembly rate for fixed physical conditi...

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Veröffentlicht in:Langmuir : the ACS journal of surfaces and colloids. - 1992. - 23(2007), 11 vom: 22. Mai, Seite 6305-14
1. Verfasser: Nykypanchuk, Dmytro (VerfasserIn)
Weitere Verfasser: Maye, Mathew M, van der Lelie, Daniel, Gang, Oleg
Format: Aufsatz
Sprache:English
Veröffentlicht: 2007
Zugriff auf das übergeordnete Werk:Langmuir : the ACS journal of surfaces and colloids
Schlagworte:Journal Article Research Support, U.S. Gov't, Non-P.H.S. Latex Macromolecular Substances DNA 9007-49-2
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245 1 0 |a DNA-based approach for interparticle interaction control 
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520 |a Micron-sized latex particles with single-stranded DNA grafted to the surface have been used as a model system to study DNA mediated interactions. A new approach of tuning the interactions between particles is proposed, which allows for a gradual change of the assembly rate for fixed physical conditions of a solution by combining hybridizing "linker" DNA with nonhybridizing "neutral" DNA. The effect of linker/neutral DNA ratios on particle assembly kinetics and aggregate morphology has been experimentally investigated for a range of ionic strengths. The conditions for controlling various assembly morphologies have been identified, and the involved attractive and repulsive interactions have been described and explained for the proposed approach. The calculated attractive-repulsive behavior is in good agreement with experimental results. The described approach provides general perspectives for further fine-tuning DNA-mediated assembly systems 
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650 4 |a Research Support, U.S. Gov't, Non-P.H.S. 
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700 1 |a Maye, Mathew M  |e verfasserin  |4 aut 
700 1 |a van der Lelie, Daniel  |e verfasserin  |4 aut 
700 1 |a Gang, Oleg  |e verfasserin  |4 aut 
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