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231223s2007 xx ||||| 00| ||eng c |
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Chong, Kwok Feng
|e verfasserin
|4 aut
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| 245 |
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|a Cell adhesion properties on photochemically functionalized diamond
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|c 2007
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|a Text
|b txt
|2 rdacontent
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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|a Date Completed 27.06.2007
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|a Date Revised 01.05.2007
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a The biocompatibility of diamond was investigated with a view toward correlating surface chemistry and topography with cellular adhesion and growth. The adhesion properties of normal human dermal fibroblast (NHDF) cells on microcrystalline and ultrananocrystalline diamond (UNCD) surfaces were measured using atomic force microscopy. Cell adhesion forces increased by several times on the hydrogenated diamond surfaces after UV irradiation of the surfaces in air or after functionalization with undecylenic acid. A direct correlation between initial cell adhesion forces and the subsequent cell growth was observed. Cell adhesion forces were observed to be strongest on UV-treated UNCD, and cell growth experiments showed that UNCD was intrinsically more biocompatible than microcrystalline diamond surfaces. The surface carboxylic acid groups on the functionalized diamond surface provide tethering sites for laminin to support the growth of neuron cells. Finally, using capillary injection, a surface gradient of polyethylene glycol could be assembled on top of the diamond surface for the construction of a cell gradient
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|a Journal Article
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|a Laminin
|2 NLM
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|a Undecylenic Acids
|2 NLM
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|a Diamond
|2 NLM
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|a 7782-40-3
|2 NLM
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| 700 |
1 |
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|a Loh, Kian Ping
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Vedula, S R K
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lim, Chwee Teck
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sternschulte, Hadwig
|e verfasserin
|4 aut
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1 |
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|a Steinmüller, Doris
|e verfasserin
|4 aut
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1 |
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|a Sheu, Fwu-Shan
|e verfasserin
|4 aut
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| 700 |
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|a Zhong, Yu Lin
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1991
|g 23(2007), 10 vom: 08. Mai, Seite 5615-21
|w (DE-627)NLM098181009
|x 0743-7463
|7 nnns
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| 773 |
1 |
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|g volume:23
|g year:2007
|g number:10
|g day:08
|g month:05
|g pages:5615-21
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