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231223s2007 xx ||||| 00| ||eng c |
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|a pubmed25n0565.xml
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|a (NLM)17397197
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Agrawal, Sarvesh K
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Micro- to nanoscale structure of biocompatible PLA-PEO-PLA hydrogels
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| 264 |
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|c 2007
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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|a Date Completed 12.06.2007
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|a Date Revised 01.12.2018
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a We observe large-scale structures in hydrogels of poly(l-lactide)-poly(ethylene oxide)-poly(l-lactide) (PLLA-PEO-PLLA) ranging in size from a few hundred nanometers to several micrometers. These structures are apparent through both ultra-small angle scattering (USAS) techniques and confocal microscopy. The hydrogels showed power law scattering in the USAS regime, which is indicative of scattering from fractal structures. The fractal dimension of the scattering from hydrogels revealed that the gels have large size aggregates with a mass fractal structure over the nanometer-to-micrometer length scales. The aggregates also seem to become more "dense" with an increase in the molecular weight of crystalline PLLA domains. Visualization through confocal microscopy confirms that the gels have a microstructure of interspersed micrometer-sized polymer inhomogeneities with water channels running between them. The presence of micrometer-sized water channels in the hydrogels has very important implications for biomedical applications
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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|a Research Support, U.S. Gov't, Non-P.H.S.
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| 650 |
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|a Biocompatible Materials
|2 NLM
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| 650 |
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7 |
|a Hydrogels
|2 NLM
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| 650 |
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|a Polyesters
|2 NLM
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| 650 |
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|a polylactide-polyethylene glycol-polylactide
|2 NLM
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| 650 |
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|a Polyethylene Glycols
|2 NLM
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| 650 |
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7 |
|a 3WJQ0SDW1A
|2 NLM
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| 700 |
1 |
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|a Sanabria-Delong, Naomi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Jemian, Pete R
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tew, Gregory N
|e verfasserin
|4 aut
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| 700 |
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|a Bhatia, Surita R
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1985
|g 23(2007), 9 vom: 24. Apr., Seite 5039-44
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnas
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| 773 |
1 |
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|g volume:23
|g year:2007
|g number:9
|g day:24
|g month:04
|g pages:5039-44
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