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231223s2007 xx ||||| 00| ||eng c |
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|a eng
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1 |
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|a Davis, Rohan A
|e verfasserin
|4 aut
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|a Synthesis and spectroscopic characterisation of a combinatorial library based on the fungal natural product 3-chloro-4-hydroxyphenylacetamide
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|c 2007
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|a Text
|b txt
|2 rdacontent
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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|a Band
|b nc
|2 rdacarrier
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|a Date Completed 30.07.2007
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|a Date Revised 04.04.2007
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|a published: Print
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|a Citation Status MEDLINE
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|a Copyright (c) 2007 John Wiley & Sons, Ltd.
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|a Parallel solution-phase chemistry has yielded a series of secondary amide analogues of the fungal natural product 3-chloro-4-hydroxyphenylacetamide. 3-Chloro-4-hydroxyphenylacetic acid was coupled to a variety of primary amines using 1-ethyl-3-(3'-dimethylamino- propyl)-carbodiimide hydrochloride. The desired products were obtained in good yield and high purity following rapid silica purification. All analogues were spectroscopically characterised using NMR, UV, IR and MS data. One compound displayed moderate cytotoxicity against the human melanoma and prostate cell lines, MM96L and DU145
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a 3-chloro-4-hydroxyphenylacetamide
|2 NLM
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|a Benzeneacetamides
|2 NLM
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| 650 |
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|a Biological Factors
|2 NLM
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| 700 |
1 |
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|a Pierens, Gregory K
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Parsons, Peter G
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Magnetic resonance in chemistry : MRC
|d 1985
|g 45(2007), 5 vom: 01. Mai, Seite 442-5
|w (DE-627)NLM098179667
|x 1097-458X
|7 nnns
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| 773 |
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|g volume:45
|g year:2007
|g number:5
|g day:01
|g month:05
|g pages:442-5
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|d 45
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|h 442-5
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