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|a pubmed24n0562.xml
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|a (DE-627)NLM168558114
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|a (NLM)17315896
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|a DE-627
|b ger
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|e rakwb
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|a eng
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|a Sandanaraj, Britto S
|e verfasserin
|4 aut
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|a Recognition and modulation of cytochrome c's redox properties using an amphiphilic homopolymer
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|c 2007
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|a Text
|b txt
|2 rdacontent
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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|a Band
|b nc
|2 rdacarrier
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|a Date Completed 15.05.2007
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|a Date Revised 21.11.2008
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a An amphiphilic homopolymer scaffold has been used to bind to the protein, cytochrome c. This interaction is analyzed using cyclic voltammetry, native gel electrophoresis, UV-visible absorption, and circular dichroism spectroscopy. The polymer binds to cytochrome c with micromolar affinity and the association of polymer with cytochrome c leads to a structural change of the protein. This conformational change exposes the heme unit of the protein, which affords an opportunity to reversibly modulate its electron-transfer properties. We have also shown that the electrostatic binding of polymer to cytochrome c can be used to disrupt its interaction with its natural partner, cytochrome c peroxidase
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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|a Research Support, Non-U.S. Gov't
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|a Cytochromes c'
|2 NLM
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|a Polymers
|2 NLM
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|a Bayraktar, Halil
|e verfasserin
|4 aut
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|a Krishnamoorthy, Kothandam
|e verfasserin
|4 aut
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|a Knapp, Michael J
|e verfasserin
|4 aut
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|a Thayumanavan, S
|e verfasserin
|4 aut
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 23(2007), 7 vom: 27. März, Seite 3891-7
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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|g volume:23
|g year:2007
|g number:7
|g day:27
|g month:03
|g pages:3891-7
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|d 23
|j 2007
|e 7
|b 27
|c 03
|h 3891-7
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