Liver aspirate from a Shar Pei dog

A 5-year-old, neutered male, Shar Pei dog was presented with weight loss, anorexia, lethargy, stranguria, and distal limb edema. Clinicopathologic abnormalities included anemia, an inflammatory leukogram, azotemia, icterus, urinary tract infection, and hepatomegaly with a markedly hypoechoic liver....

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Veröffentlicht in:Veterinary clinical pathology. - 1975. - 36(2007), 1 vom: 07. März, Seite 105-8
1. Verfasser: Flatland, Bente (VerfasserIn)
Weitere Verfasser: Moore, Rebecca R, Wolf, Christina M, Yeomans, Stephen M, Donnell, Robert L, Lane, India F, Fry, Michael M
Format: Aufsatz
Sprache:English
Veröffentlicht: 2007
Zugriff auf das übergeordnete Werk:Veterinary clinical pathology
Schlagworte:Case Reports Journal Article
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100 1 |a Flatland, Bente  |e verfasserin  |4 aut 
245 1 0 |a Liver aspirate from a Shar Pei dog 
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500 |a Date Revised 10.11.2019 
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520 |a A 5-year-old, neutered male, Shar Pei dog was presented with weight loss, anorexia, lethargy, stranguria, and distal limb edema. Clinicopathologic abnormalities included anemia, an inflammatory leukogram, azotemia, icterus, urinary tract infection, and hepatomegaly with a markedly hypoechoic liver. Cytologic findings in a fine-needle aspirate of the liver included large amounts of amorphous, pink, extracellular matrix between hepatocytes. The amorphous material was congophilic using Congo red stain on a hepatic cytology specimen and green birefringent areas were observed under polarized light, confirming the presence of amyloid. The dog was euthanized and a necropsy was done. Histopathologic evaluation using H&E and Congo red staining confirmed amyloid deposits within the liver, kidneys, intestinal vessels, pancreas, and mesenteric ganglia. Immunohistochemical staining of liver and kidney sections using anti-AA amyloid and anti-P component antibodies confirmed the presence of AA amyloid. In this case, we demonstrated that Congo red staining and polarized light microscopy are a useful diagnostic technique in cytologic specimens of suitable thickness for confirming the presence of amyloid 
650 4 |a Case Reports 
650 4 |a Journal Article 
700 1 |a Moore, Rebecca R  |e verfasserin  |4 aut 
700 1 |a Wolf, Christina M  |e verfasserin  |4 aut 
700 1 |a Yeomans, Stephen M  |e verfasserin  |4 aut 
700 1 |a Donnell, Robert L  |e verfasserin  |4 aut 
700 1 |a Lane, India F  |e verfasserin  |4 aut 
700 1 |a Fry, Michael M  |e verfasserin  |4 aut 
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