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231223s2007 xx ||||| 00| ||eng c |
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|a (NLM)17269809
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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|a Sachl, Radek
|e verfasserin
|4 aut
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|a Preparation and characterization of self-assembled nanoparticles formed by poly(ethylene oxide)-block-poly(epsilon-caprolactone) copolymers with long poly(epsilon-caprolactone) blocks in aqueous solutions
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|c 2007
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|a Text
|b txt
|2 rdacontent
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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|a Band
|b nc
|2 rdacarrier
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|a Date Completed 06.07.2007
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|a Date Revised 01.12.2018
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Aqueous solutions of self-assembled nanoparticles formed by biocompatible diblock copolymers of poly(epsilon-caprolactone)-block-poly(ethylene oxide) (PCL-PEO) with the same molar mass of the PEO block (5000 g mol-1) and three different molar masses of the PCL block (5000, 13 000, and 32 000 g mol-1) have been prepared by a fast mixing the copolymer solution in a mild selective solvent, tetrahydrofuran (THF)/water, with an excess of water, that is, by quenching the reversible micellization equilibrium, and a subsequent removal of THF by dialysis of the water-rich solution against water. The prepared nanoparticles have been characterized by static and dynamic light scattering and atomic force microscopy imaging. It was found that stable monodisperse nanoparticles are formed only if the initial mixed solvent contained 90 vol % THF. The results show that the prepared nanoparticles are spherical vesicles with relatively thick hydrophobic walls, that is, spherical core/shell nanoparticles with the hollow core filled with the solvent
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Drug Carriers
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|a Furans
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|a Micelles
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|a Polyesters
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|a Polymers
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|a Solvents
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|a Water
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|a polycaprolactone
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|a tetrahydrofuran
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|a Polyethylene Glycols
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|a 3WJQ0SDW1A
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|a Uchman, Mariusz
|e verfasserin
|4 aut
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|a Matĕjícek, Pavel
|e verfasserin
|4 aut
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|a Procházka, Karel
|e verfasserin
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|a Stĕpánek, Miroslav
|e verfasserin
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|a Spírková, Milena
|e verfasserin
|4 aut
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 23(2007), 6 vom: 13. März, Seite 3395-400
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
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|g volume:23
|g year:2007
|g number:6
|g day:13
|g month:03
|g pages:3395-400
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|h 3395-400
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