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20231223113926.0 |
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231223s2007 xx ||||| 00| ||eng c |
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|a (DE-627)NLM167886622
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|a (NLM)17243738
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Pathak, Pankaj
|e verfasserin
|4 aut
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| 245 |
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|a Nanosized paclitaxel particles from supercritical carbon dioxide processing and their biological evaluation
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|c 2007
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|a Text
|b txt
|2 rdacontent
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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|a Band
|b nc
|2 rdacarrier
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|a Date Completed 27.06.2007
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|a Date Revised 19.11.2015
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a The rapid expansion of a supercritical solution into a liquid solvent (RESOLV) technique with benign supercritical carbon dioxide was applied to obtain aqueous suspended nanoparticles of the highly potent anticancer drug paclitaxel. The paclitaxel nanoparticles were protected from agglomeration by using a known nontoxic stabilization agent. The aqueous suspended paclitaxel nanoparticles of different average particle sizes were evaluated in vitro against human breast cancer cells. The results suggest that the nanosized paclitaxel particles are effective, with an antineoplastic activity comparable to that of the commercial paclitaxel formulation. The technique should be generally applicable to the processing of nanoparticles from other important drugs with aqueous solubility problems
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Research Support, U.S. Gov't, Non-P.H.S.
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|a Antineoplastic Agents, Phytogenic
|2 NLM
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| 650 |
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7 |
|a Solvents
|2 NLM
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| 650 |
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|a Carbon Dioxide
|2 NLM
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| 650 |
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|a 142M471B3J
|2 NLM
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| 650 |
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|a Paclitaxel
|2 NLM
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| 650 |
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|a P88XT4IS4D
|2 NLM
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| 700 |
1 |
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|a Prasad, Gaddamanugu L
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Meziani, Mohammed J
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Joudeh, Attalla A
|e verfasserin
|4 aut
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| 700 |
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|a Sun, Ya-Ping
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 23(2007), 5 vom: 27. Feb., Seite 2674-9
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
1 |
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|g volume:23
|g year:2007
|g number:5
|g day:27
|g month:02
|g pages:2674-9
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