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|e rakwb
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|a eng
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| 100 |
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|a Schiltz, M
|e verfasserin
|4 aut
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|a Modelling and refining site-specific radiation damage in SAD/MAD phasing
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|c 2007
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|a Text
|b txt
|2 rdacontent
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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|b nc
|2 rdacarrier
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|a Date Completed 06.03.2007
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|a Date Revised 09.01.2007
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Site-specific radiation damage on anomalously scattering sites can be used to generate additional phase information in standard single- or multi-wavelength anomalous diffraction (SAD or MAD) experiments. In this approach the data are kept unmerged, down to the Harker construction, and the evolution of site-specific radiation damage as a function of X-ray irradiation is explicitly modelled and refined in real space. Phasing power is generated through the intensity differences of symmetry-related reflections or repeated measurements of the same reflection recorded at different X-ray doses. In the present communication the fundamentals of this approach are reviewed and different models for the description of site-specific radiation damage are presented. It is shown that, in more difficult situations, overall radiation damage may unfold on a time scale that is similar to the evolution of site-specific radiation damage or to the total time that is required to record a complete data set. In such cases the quality of the phases will ultimately be limited by the effects of overall radiation damage
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Macromolecular Substances
|2 NLM
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|a Bricogne, G
|e verfasserin
|4 aut
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|i Enthalten in
|t Journal of synchrotron radiation
|d 1994
|g 14(2007), Pt 1 vom: 01. Jan., Seite 34-42
|w (DE-627)NLM09824129X
|x 0909-0495
|7 nnns
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| 773 |
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|g volume:14
|g year:2007
|g number:Pt 1
|g day:01
|g month:01
|g pages:34-42
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|d 14
|j 2007
|e Pt 1
|b 01
|c 01
|h 34-42
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