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01000caa a22002652 4500 |
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NLM167549839 |
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DE-627 |
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20250207222239.0 |
| 007 |
tu |
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231223s2007 xx ||||| 00| ||chi c |
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5 |
2 |
|a pubmed25n0559.xml
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| 035 |
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|a (DE-627)NLM167549839
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| 035 |
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|a (NLM)17207355
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| 040 |
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a chi
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| 100 |
1 |
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|a Shang, Dong
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Role of polymorphonuclear neutrophil apoptosis and expression of Fas and caspase-3 in the systemic inflammatory response syndrome
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| 264 |
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1 |
|c 2007
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 07.07.2009
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| 500 |
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|a Date Revised 16.11.2017
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| 500 |
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|a published: Print
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| 500 |
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|a Citation Status MEDLINE
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| 520 |
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|a OBJECTIVE: To study the role of the polymorphonuclear neutrophil (PMN) apoptosis and expression of Fas and caspase-3 in the systemic inflammatory response syndrome (SIRS)
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| 520 |
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|a METHODS: Eight acute pancreatitis patients with SIRS, 6 healthy control subjects were enrolled to study apoptosis of PMN in peripheral blood samples, expression of Fas/Fas ligand (FasL) and caspase-3 in the PMN, the levels of serum interleukin-6 (IL-6) and IL-8 were observed
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| 520 |
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|a RESULTS: Spontaneous apoptosis was significantly delayed in PMN from the SIRS patients with higher serum IL-6 and IL-8 levels compared with controls (both P<0.01). PMN apoptosis rate in peripheral blood of patients with SIRS was lowered than that of controls (P<0.01). The expressions of Fas and caspase-3 in the peripheral circulating PMN were higher in the controls than those in the SIRS patients (both P<0.01). Serum FasL expression was not found by Western blotting 24 hours after culture of PMN in vitro
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| 520 |
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|a CONCLUSION: Peripheral circulating PMN from acute pancreatitis patients with SIRS show delayed apoptosis, decreased expressions of Fas and caspase-3, and prolonged PMN survival may contribute to the development of systemic inflammatory injury characteristic of SIRS
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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7 |
|a Fas Ligand Protein
|2 NLM
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| 650 |
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7 |
|a Interleukin-6
|2 NLM
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| 650 |
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7 |
|a Interleukin-8
|2 NLM
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| 650 |
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7 |
|a fas Receptor
|2 NLM
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| 650 |
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7 |
|a Caspase 3
|2 NLM
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| 650 |
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7 |
|a EC 3.4.22.-
|2 NLM
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| 700 |
1 |
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|a Qi, Qing-hui
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Bao-zhi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, Hai-long
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Bi, Wei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Guan, Feng-lin
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue
|d 1998
|g 19(2007), 1 vom: 08. Jan., Seite 11-3
|w (DE-627)NLM098227793
|x 1003-0603
|7 nnns
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| 773 |
1 |
8 |
|g volume:19
|g year:2007
|g number:1
|g day:08
|g month:01
|g pages:11-3
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| 912 |
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
|
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|d 19
|j 2007
|e 1
|b 08
|c 01
|h 11-3
|