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231223s2007 xx ||||| 00| ||eng c |
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|a (NLM)17190504
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|a DE-627
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|e rakwb
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|a eng
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| 100 |
1 |
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|a Das, Mallika
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Microgels loaded with gold nanorods
|b photothermally triggered volume transitions under physiological conditions
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| 264 |
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|c 2007
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|a Text
|b txt
|2 rdacontent
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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|a Band
|b nc
|2 rdacarrier
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|a Date Completed 06.02.2007
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|a Date Revised 27.12.2006
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|a published: Print
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|a Citation Status PubMed-not-MEDLINE
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|a Photothermally driven volume transitions in polymer microgels have promising applications for site-specific drug delivery and photodynamic therapy. We studied the temperature-induced volume phase transitions for a series of thermoresponsive microgels of various compositions to find a system with a sharp transition in the physiologically relevant range spanning 38-41 degrees C in 0.01 M phosphate-buffered saline solution (pH = 7.4). We found that the poly(N-isopropylacrylamide-maleic acid) microgels showed an 8-fold decrease in size under the aforementioned conditions. These microgels were loaded with gold nanorods designed to absorb in the near-IR spectral range. Following irradiation at lambda = 809 nm, the microgels underwent a large, reversible, photothermally triggered change in volume. We believe that this microgel system is a promising candidate for photothermally controlled drug release
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|a Journal Article
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1 |
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|a Sanson, Nicolas
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Fava, Daniele
|e verfasserin
|4 aut
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| 700 |
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|a Kumacheva, Eugenia
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 23(2007), 1 vom: 02. Jan., Seite 196-201
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|x 1520-5827
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|g volume:23
|g year:2007
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|g pages:196-201
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|d 23
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