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231223s2006 xx ||||| 00| ||chi c |
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|a (NLM)17083780
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|a DE-627
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|c DE-627
|e rakwb
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| 041 |
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|a chi
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| 100 |
1 |
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|a Feng, Zhi-chun
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Continuous blood purification in the treatment of pediatric septic shock
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|c 2006
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
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|2 rdacarrier
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|a Date Completed 03.08.2010
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|a Date Revised 30.03.2022
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|a published: Print
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|a Citation Status MEDLINE
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| 520 |
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|a OBJECTIVE: To investigate the efficacy of continuous blood purification (CBP) and to explore its mechanism in the treatment of pediatric septic shock
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|a METHODS: Nine children weighted 3.1 kg - 14.0 kg with septic shock were treated with continuous veno-venous hemofiltration (CVVH) which is also referred to as CBP with blood access of double-lumen hemodialysis catheter of 6.5 to 8Fr inserted via central vein, hemofilters of Minifilter plus (for children with body weight < 5 kg) or AV400s (for children with body weight > or = 5 kg), child's type extracorporeal circuit vessel and heparin anticoagulation. The replacement solution was delivered pre-dilution after 3 to 4 hours' post-dilution. The blood gas, clinical biochemical items, medium molecule substance (MMS) concentration in blood as well as capillary refill time (CRT), BP, urine output, vasopressors dosage were examined at a set of time points from the beginning to the end of the CVVH
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|a RESULTS: Of the 9 children, 6 had acute renal failure (ARF), 3 had acute respiratory distress syndrome (ARDS), 5 were blood culture positive and all the 9 needed vasopressors to keep BP before CVVH. The blood pH was 7.14 +/- 0.23, base excess (BE) was -11.3 +/- 4.25 mmol/L, MMS was 3532 +/- 519 U/L, PO2/FiO2 was 188 +/- 33, CRT > 5 s, urine output was 0.85 +/- 0.52 ml/(kg.hr) and the adrenalin dosage 1.36 +/- 0.48 microg/(kg.min), and dopamine 16.35 +/- 3.27 microg/(kg.min) before CVVH. The patients' condition was improved much as demonstrated by pH 7.38 +/- 0.16, BE -0.28 +/- 1.37 mmol/L, MMS 2576 +/- 375 U/L, PO2/FiO2 285 +/- 63, CRT < 2 s, and the adrenalin dosage 0.08 +/- 0.04 microg/(kg.min) and dopamine 8.53 +/- 6.72 microg/(kg.min), urine output 2.9 +/- 1.6 ml/(kg.hr) after 24 hour treatment with CVVH. Of the 9 children, 2 died of MODS (1 intussusception complicated with intestine necrosis, 1 severe scald) and 1 was given up because of severe intestinal fistula, the other 6 children recovered at the end
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|a CONCLUSION: CBP was effective in treatment of pediatric septic shock by improving the oxygenation, correcting metabolic acidosis, stabilizing BP, increasing the tissue perfusion and eliminating the medium molecule substances
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|a Journal Article
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| 700 |
1 |
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|a Chang, Ping
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tao, Shao-hua
|e verfasserin
|4 aut
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| 700 |
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|a Chen, Hui
|e verfasserin
|4 aut
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| 773 |
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8 |
|i Enthalten in
|t Zhonghua er ke za zhi = Chinese journal of pediatrics
|d 1960
|g 44(2006), 8 vom: 06. Aug., Seite 579-82
|w (DE-627)NLM136249191
|x 0578-1310
|7 nnns
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|g volume:44
|g year:2006
|g number:8
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|g month:08
|g pages:579-82
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