Immunosuppressive activity of a new pteridine derivative (4AZA1378) alleviates severity of TNBS-induced colitis in mice

Immunosuppressive activity of a new pteridine derivative (4AZA1378) alleviates severity of TNBS-induced colitis in mice

Besides TNF, activated T cells play a central role in the pathogenesis of inflammatory bowel diseases such as Crohn's disease. New therapies are still awaited to cure these often debilitating diseases. Natural occurring pteridines such as tetrahydrobiopterin (BH4) and neopterin have been report...

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Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 122(2007), 1 vom: 01. Jan., Seite 53-61
1. Verfasser: Shen, Chong (VerfasserIn)
Weitere Verfasser: Dillissen, Ellen, Kasran, Ahmad, Lin, Yuan, Herman, Jean, Sienaert, Ilse, De Jonghe, Steven, Kerremans, Luk, Geboes, Karel, Boon, Louis, Rutgeerts, Paul, Ceuppens, Jan L
Format: Aufsatz
Sprache:English
Veröffentlicht: 2007
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article 4AZA1378 Cytokines Immunosuppressive Agents Pteridines Trinitrobenzenesulfonic Acid 8T3HQG2ZC4 Peroxidase EC 1.11.1.7