Epitope clustering in regions undergoing efficient proteasomal processing defines immunodominant CTL regions of a tumor antigen

Epitope clustering in regions undergoing efficient proteasomal processing defines immunodominant CTL regions of a tumor antigen

Identification of immunodominant CD8(+) T cell responses to frequently expressed tumor antigens across MHC class I polymorphism is essential for the implementation of cancer immunotherapy. However, the key factors that determine immunodominance are not fully understood. Because of its frequent expre...

Ausführliche Beschreibung

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 122(2007), 2 vom: 01. Feb., Seite 163-72
1. Verfasser: Valmori, Danila (VerfasserIn)
Weitere Verfasser: Lévy, Frédéric, Godefroy, Emmanuelle, Scotto, Luigi, Souleimanian, Naira E, Karbach, Julia, Tosello, Valeria, Hesdorffer, Charles S, Old, Lloyd J, Jager, Elke, Ayyoub, Maha
Format: Aufsatz
Sprache:English
Veröffentlicht: 2007
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Antigens, Neoplasm CTAG1B protein, human Cancer Vaccines Epitopes, T-Lymphocyte Immunodominant Epitopes Membrane Proteins Proteasome Endopeptidase Complex EC 3.4.25.1