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01000naa a22002652 4500 |
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NLM166098361 |
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DE-627 |
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20231223110107.0 |
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tu |
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231223s2007 xx ||||| 00| ||eng c |
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|a pubmed24n0554.xml
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|a (DE-627)NLM166098361
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|a (NLM)17052956
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Zhang, Zheng
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Increased infiltration of intrahepatic DC subsets closely correlate with viral control and liver injury in immune active pediatric patients with chronic hepatitis B
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|c 2007
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|a Text
|b txt
|2 rdacontent
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 07.03.2007
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|a Date Revised 21.03.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a The roles of functionally impaired dendritic cells (DCs) in natural history of chronic hepatitis B (CHB) are unknown. We therefore characterized circulating DC subsets in 15 immune tolerant (IT) and 31 immune active (IA) HBV-infected children. Additionally, intrahepatic DC subsets were also analyzed in 4 IT and 9 IA individuals. The results showed that circulating DC subset numbers were decreased, but the intrahepatic DC counts were concomitantly increased in IA patients versus IT patients or healthy children. This results in the reduction of overall IFN-alpha but not IL-12 production by peripheral blood mononuclear cells of IA patients, although the capacity of single DC in producing cytokines was unchanged in these children. Moreover, there is a significantly inverse correlation of intrahepatic DC subsets with plasma HBV load and a positive correlation with serum ALT levels. These findings suggest that the increased infiltration of intrahepatic DC subsets may participate in the local antiviral immune response in pediatric patients with CHB
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| 650 |
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|a Journal Article
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| 650 |
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|a Research Support, Non-U.S. Gov't
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| 700 |
1 |
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|a Chen, Dawei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yao, Jinxia
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Hui
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Jin, Lei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Shi, Ming
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Hongfei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Fu-Sheng
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 122(2007), 2 vom: 10. Feb., Seite 173-80
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:122
|g year:2007
|g number:2
|g day:10
|g month:02
|g pages:173-80
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| 912 |
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_11
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| 912 |
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|a GBV_ILN_24
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 122
|j 2007
|e 2
|b 10
|c 02
|h 173-80
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