Kinetics of FcRn-mediated recycling of IgG and albumin in human pathophysiology and therapeutic implications using a simplified mechanism-based model

Kinetics of FcRn-mediated recycling of IgG and albumin in human : pathophysiology and therapeutic implications using a simplified mechanism-based model

The nonclassical MHC class-I molecule, FcRn, salvages both IgG and albumin from degradation. Here we introduce a mechanism-based kinetic model for human to quantify FcRn-mediated recycling of both ligands based on saturable kinetics and data from the literature using easily measurable plasma concent...

Ausführliche Beschreibung

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 122(2007), 2 vom: 01. Feb., Seite 146-55
1. Verfasser: Kim, Jonghan (VerfasserIn)
Weitere Verfasser: Hayton, William L, Robinson, John M, Anderson, Clark L
Format: Aufsatz
Sprache:English
Veröffentlicht: 2007
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Comparative Study Journal Article Research Support, N.I.H., Extramural Histocompatibility Antigens Class I Immunoglobulin G Receptors, Fc Serum Albumin Fc receptor, neonatal TW3XAW0RCY