The mannan-binding lectin pathway and lung disease in cystic fibrosis--disfunction of mannan-binding lectin-associated serine protease 2 (MASP-2) may be a major modifier

The mannan-binding lectin pathway and lung disease in cystic fibrosis--disfunction of mannan-binding lectin-associated serine protease 2 (MASP-2) may be a major modifier

The lectin pathway of complement activation is initiated by mannan-binding lectin (MBL) or the ficolins through the common MBL-associated serine protease-2 (MASP-2). Deficiency of MBL has been associated with poorer outcome in cystic fibrosis (CF). We investigated the MBL pathway further by analysis...

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Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 121(2006), 3 vom: 01. Dez., Seite 324-31
1. Verfasser: Olesen, H V (VerfasserIn)
Weitere Verfasser: Jensenius, J C, Steffensen, R, Thiel, S, Schiøtz, P O
Format: Aufsatz
Sprache:English
Veröffentlicht: 2006
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Mannose-Binding Lectin MASP2 protein, human EC 3.4.21.- Mannose-Binding Protein-Associated Serine Proteases