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01000naa a22002652 4500 |
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NLM165794127 |
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DE-627 |
| 005 |
20231223105448.0 |
| 007 |
tu |
| 008 |
231223s2007 xx ||||| 00| ||eng c |
| 028 |
5 |
2 |
|a pubmed24n0553.xml
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| 035 |
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|a (DE-627)NLM165794127
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| 035 |
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|a (NLM)17020818
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| 040 |
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Umemura, Takeji
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a Lack of association between FCRL3 and FcgammaRII polymorphisms in Japanese type 1 autoimmune hepatitis
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| 264 |
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1 |
|c 2007
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 11.04.2007
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| 500 |
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|a Date Revised 13.02.2007
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| 500 |
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|a published: Print-Electronic
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| 500 |
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|a Citation Status MEDLINE
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| 520 |
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|a Autoimmune hepatitis (AIH) is an organ-specific autoimmune disease characterized by chronic inflammation of the liver. Although the HLA-DRB1*0405 allele is associated with type 1 AIH in Japanese, the exact genetic etiology of AIH remains undefined. Recently, polymorphisms of Fcgamma receptors (FcgammaR) and Fc receptor-like gene 3 (FCRL3) were linked to a variety of autoimmune diseases, and may be at least partially responsible for susceptibility to AIH. In this study, we genotyped FcgammaRIIA, FcgammaRIIB, and four FCRL3 polymorphisms in 87 Japanese patients with type 1 AIH and 97 ethnically matched controls using the TaqMan assay. Although we were able to detect significantly lower serum IgG concentrations in AIH patients specifically with the FCRL3-110A/A genotype, we observed no difference in the distribution of the genotypes between patients and controls, implying that susceptibility to type 1 AIH in Japanese patients is not influenced by FcgammaRIIA, FcgammaRIIB, or FCRL3 polymorphisms
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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7 |
|a Antigens, CD
|2 NLM
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| 650 |
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7 |
|a FCGR2B protein, human
|2 NLM
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| 650 |
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7 |
|a FCRL3 protein, human
|2 NLM
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| 650 |
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7 |
|a Fc gamma receptor IIA
|2 NLM
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| 650 |
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7 |
|a Receptors, IgG
|2 NLM
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| 650 |
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7 |
|a Receptors, Immunologic
|2 NLM
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| 700 |
1 |
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|a Ota, Masao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yoshizawa, Kaname
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Katsuyama, Yoshihiko
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ichijo, Tetsuya
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tanaka, Eiji
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kawa, Shigeyuki
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kiyosawa, Kendo
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 122(2007), 3 vom: 22. März, Seite 338-42
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:122
|g year:2007
|g number:3
|g day:22
|g month:03
|g pages:338-42
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| 912 |
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_11
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| 912 |
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|a GBV_ILN_24
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 122
|j 2007
|e 3
|b 22
|c 03
|h 338-42
|