Encapsulation and selective recognition of molecularly imprinted theophylline and 17beta-estradiol nanoparticles within electrospun polymer nanofibers

Molecularly imprinted nanoparticles are cross-linked polymer colloids containing tailor-made molecular recognition sites. In this study, molecularly imprinted nanoparticles were easily encapsulated within polymer nanofibers using an electrospinning technique to produce a new type of molecular recogn...

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Veröffentlicht in:Langmuir : the ACS journal of surfaces and colloids. - 1992. - 22(2006), 21 vom: 10. Okt., Seite 8960-5
1. Verfasser: Chronakis, Ioannis S (VerfasserIn)
Weitere Verfasser: Jakob, Alexandra, Hagström, Bengt, Ye, Lei
Format: Aufsatz
Sprache:English
Veröffentlicht: 2006
Zugriff auf das übergeordnete Werk:Langmuir : the ACS journal of surfaces and colloids
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Polyesters Polyethylene Terephthalates Polyethylene Glycols 3WJQ0SDW1A Estradiol 4TI98Z838E Theophylline C137DTR5RG
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245 1 0 |a Encapsulation and selective recognition of molecularly imprinted theophylline and 17beta-estradiol nanoparticles within electrospun polymer nanofibers 
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520 |a Molecularly imprinted nanoparticles are cross-linked polymer colloids containing tailor-made molecular recognition sites. In this study, molecularly imprinted nanoparticles were easily encapsulated within polymer nanofibers using an electrospinning technique to produce a new type of molecular recognition material. Poly(ethylene terephthalate) (PET) was used as the supporting nanofibers matrix to encapsulate theophylline and 17beta-estradiol imprinted nanoparticles. The composite nanofibers had an average diameter of 150-300 nm, depending on the content of molecularly imprinted nanoparticles. For the theophylline and 17beta-estradiol imprinted polymers, an optimal loading of molecularly imprinted nanoparticles was 25-37.5 wt % based on PET. The composite nanofibers prepared under these conditions had a well-defined morphology and displayed the best selective target recognition. Our approach of electrospinning-for-molecularly imprinted nanoparticles-encapsulation has unique advantages and opens new application opportunities for molecularly imprinted nanoparticles and electrospun nanofibers 
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650 4 |a Research Support, Non-U.S. Gov't 
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700 1 |a Jakob, Alexandra  |e verfasserin  |4 aut 
700 1 |a Hagström, Bengt  |e verfasserin  |4 aut 
700 1 |a Ye, Lei  |e verfasserin  |4 aut 
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